Dr M Hamann, Prof Flaviano Giorgini
No more applications being accepted
Competition Funded PhD Project (UK Students Only)
About the Project
Studies on noise-induced hearing loss classically focus on the drastic damage inflicted upon cochlear hair cells. Noise-induced hearing loss is often visible after a few months, as the cochlear damage becomes irreversible. Stress granules are cytoplasmic aggregates of proteins and RNAs that appear under stress conditions. Our recent studies have identified stress granules in cochlear hair cells minutes following acoustic over-exposure.
The project will explore whether cochlear stress granules are biomarkers of the early stages of hidden hearing loss. The presence of stress granules will be evaluated by immunofluorescence for specific stress granule markers. Proteomic and transcriptomic analysis will provide mechanistic insights into their function and their specific link to signalling pathways. The project will also test the ability of antioxidants to reduce the presence of stress granules and stop or delay the damage of cochlear structures that is indicative of permanent hearing loss.
Funding Notes
This is an Integrative Midlands Partnership for Biomedical Training (IMPACT): MRC-funded doctoral training partnership between the universities of Birmingham, Leicester and Nottingham,
Eligiibility : British nationals who have lived in the UK all their lives are eligible. Also eligible are non-British nationals who have settled status (i.e. no restrictions on how long they can stay in the UK) AND have been resident in the UK for 3 years immediately prior to the date of the start of the course. EU nationals, EEA and Swiss nationals (EEA migrant workers) should refer to the full RCUK guidelines to check eligibility (you may be eligible for a fees only award)
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