Biomolecular design to target neurotoxic protein oligomers in Parkinson’s disease

Oligomeric species populated during the aggregation process of α synuclein have been linked to neuronal impairment in Parkinson’s disease (PD). Targeting these toxic species is expected to impact significantly our ability to combat PD. We have recently been able to study the structure of elusive α-synuclein oligomers and to characterise the key mechanism underlying their neurotoxicity in PD (Fusco et al, Science 2017, 358:1440-43). Based on this structural information, the project aims at developing the next generation of biomolecules able to suppress the toxicity of relevant α-synuclein oligomers using the latest drug discovery biotechnologies.

For information contact: [Email Address Removed]

To apply for this studentship, please visit the Imperial College & Royal Holloway BBSRC DTP website: http://www.imperial.ac.uk/bbsrc-doctoral-training-partnership/