Dynamic regulation and interpretation of ubiquitin modifications by endosomal sorting complexes

We seek a highly motivated student to join our research team within a dynamic molecular cell biology research laboratory. Our laboratory has a long-standing interest and expertise in studying the molecular machineries that regulate growth factor receptor trafficking through the endolysosmal pathway in mammalian cells. We are particularly interested in enzymes that modulate the key sorting signal, ubiquitin, that is attached to endosomal cargos. Amongst these we have specialised in the analysis of deubiquitylases, the enzymes that remove ubiquitin from proteins. We seek to understand the modes of ubiquitin chain recognition and editing associated with endo-lysosomal degradative pathways. We will use a wide range of cell biological approaches including cell fractionation, proteomics and imaging techniques. This studentship is integrated into an European Research Training Programme (Marie Curie Innovative Training Network (ITN) UbiCODE) and also provides access to specialised training courses at different European host institutions throughout the training period. Interested candidates should hold a good first degree in a life sciences.

Students should not have spent more than 12 months during the last 3 years in the UK for this particular post.
Selected students might be interviewed by Skype in April 2018. Final selection is expected to be finished in May 2018. Students are expected to initiate their contracts in SEPTEMBER 1st 2018. The present contract will last for three years.

For further details on the content of our research program and the application procedure please visit any of these links:
EURAXESS :https://euraxess.ec.europa.eu/jobs/271565
Website: http://ubicode.eu/

Additional informal enquiries can be directed to Prof Sylvie Urbé email: [Email Address Removed] and Prof Michael Clague [Email Address Removed]