• National University of Singapore Featured PhD Programmes
  • University of Warwick Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of East Anglia Featured PhD Programmes
  • Northumbria University Featured PhD Programmes
  • University College London Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
University of York Featured PhD Programmes
University of Surrey Featured PhD Programmes
National Institute of Agricultural Botany (NIAB) Featured PhD Programmes
Newcastle University Featured PhD Programmes
University of Reading Featured PhD Programmes

Engineering bacteriophages to combat antimicrobial resistance


Project Description

The rise in antimicrobial resistance is predicted to result in up to 10 million deaths per year by 2050. Therefore, alternative antibiotics are needed to combat the rise in antimicrobial resistance. Bacteriophages (phages) are viruses that specifically infect bacteria and can be used as alternatives to traditional antibiotics.

This project will build on existing expertise in the engineering of bacteriophages. Bringing the experience from three supervisors Dr Andrew Millard (www.millardlab.org) and Prof Martha Clokie (https://www2.le.ac.uk/departments/iii/people/dr-martha-clokie) at the University of Leicester and Dr Nick Waterfield (https://warwick.ac.uk/fac/med/staff/nwaterfield/) at the University of Warwick.

The aim of the project will be to further engineer bacteriophages to target multiple species of bacteria within polymicrobial infections. Using synthetic biology approaches and a genetic system we already have established, different payloads will be incorporated into bacteriophage genomes. The efficacy of these payloads at targeting different bacterial species will be tested using both in vitro and in vivo models (Galleria mellonella & Manduca sexta).

The project will involve molecular biology, genome sequencing, microbiology, and bioinformatics analysis. Experience in working with bacteriophages is highly desirable and the willingness to become familiar with linux and bioinformatics analyses is essential.

Skills training/methods/techniques:
• Microbiological assays
• Genome sequencing
• Analysis of genome sequencing data
• General molecular techniques
• Protein expression

Funding Notes

3 Year CLS Funded Studentship. Funding provides UK/EU fee waiver and Stipend at UK Research Council rates for 3 years.
Available to UK/EU applicants only

Related Subjects

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully




Cookie Policy    X