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Discovery of novel immune gene editing mechanisms in invertebrates

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

About This PhD Project

Project Description

A newly established laboratory is seeking highly motivated PhD/MSc candidates to study non-classical immune systems that utilize genome editing mechanisms to create enhanced immune gene repertoire.

By using single cell genomics combined with long read NGS technologies (PacBio, Nanopore), we have recently discovered that the sea urchin immune system is subjected to genomic rearrangements in somatic cells, resulting in exceptionally high immune gene diversity (https://www.youtube.com/watch?v=SDrFJkqkumM). Evidences for other genome editing processes with similar characteristics exist in other organisms.

Our goal is to discover and explore these genome editing mechanisms and to identify the regulatory elements controlling them.

Highly motivated candidates with a relevant degree are encouraged to apply. Successful candidates should be fluent in English with experience in molecular biology and/or bioinformatics techniques.

Ariel University offers a collaborative and friendly research environment. PhD/MSc students are offered a full competitive scholarship.

For further details you are encouraged to contact me directly. Please include a short background and CV.

References

Relevant publications:

Oren M, Barela Hudgell MA, D'Allura B, Agronin J, Gross A, Podini D, Smith CL. Short tandem repeats, segmental duplications, gene deletion, and genomic instability in a rapidly diversified immune gene family. BMC genomics. 2016. 17(900). doi: 10.1186/s12864-016-3241

Majeske AJ*, Oren M*, Sacchi S, Smith CL. Single sea urchin phagocytes express messages of a single sequence from the diverse Sp185/333 gene family in response to bacterial challenge. The Journal of Immunology. 2014. 193(11):5678-88. doi: 10.4049. *Equal contribution.

Oren M, Hudgell MAB, Golconda P, Man Lun C, Smith CL. Genomic instability and shared mechanisms for gene diversification in two distant immune gene families: the echinoid 185/333 and the plant NBS-LRR. Book chapter 12, “The Evolution of the immune systems: conservation and diversification”. 2016. D. Malagoli. London, UK, Elsevier-Academic Press: 295-310.

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