Metastasis is the leading cause of death in cancer patients, and is difficult to treat. Metastasis involves complex biological and physical interactions between cancer cells and their microenvironment. Our understanding of events leading to metastasis is limited by the significant gap between currently available in vitro models (e.g. lack of tumour heterogeneity and microenvironmental interactions) and in vivo models (genetic differences between mice and humans, low throughput). This together hampers the development of drugs to target steps of metastasis. This PhD project proposes to develop a novel bioengineered microfluidic culture system, which combines simulated cancer heterogeneity with microenvironmental complexity. This will increase our understanding of critical steps of the metastatic cascade, and provide a prototype preclinical assay system with greater predictive power for drug development.
Applications are welcomed from candidates with a background in engineering, biological sciences, physics or related subjects. An ability to think ’outside the box’ is highly desirable. This is a multi-disciplinary project where the applicant will interact with researchers from different research backgrounds, thus good organisation, team working and communication skills are also highly desirable.
To request further details of this project contact Dr Yan Yan Shery Huang - [email protected]
Applicants should have (or expect to obtain by the start date)First Class or high 2:1 (over 65% or equivalent) undergraduate degree in engineering, biological science, physics or related subjects, possibly supported by an MSc degree.
This studentship will pay full University fees and a maintenance allowance of at least £14,582 per year for UK students. EU citizens are eligible for a fees only award.
Overseas students are not eligible for this Studentship and should not apply.
Please contact Dr Shery Huang for informal discussion prior to your formal application submission.