Understanding mechanisms of bone loss in inflammatory bowel disease - Project ID SAS0017

Crohn’s disease and ulcerative colitis, the major forms of inflammatory bowel disesase (IBD), are chronic conditions of the intestinal tract. IBD affects up to 1 in 250 people in the UK, with a recent National Health Service review estimating costs of £730 million per year. Individuals with IBD often present with poor bone health. The development of targeted therapies for this bone loss requires a better understanding of the underlying cellular mechanisms. This project will therefore contribute to ongoing work in our lab looking at mechanisms of IBD-related poor bone health.

This project will use both in vitro and in vivo models to interrogate the mechanisms of IBD-related bone loss. Techniques which will be used include (but are not limited to): cell culture, RT-qPCR, western blotting, immunohistochemistry, ex vivo microCT, histology, cell imaging, confocal microscopy.

This work will inform therapeutic strategies for improving the health and wellbeing of patients with IBD.


Academic qualifications
A first degree (at least a 2.1) ideally in Biology with a good fundamental knowledge of laboratory skills and biomedical science.

English language requirement
IELTS score must be at least 6.5 (with not less than 6.0 in each of the four components). Other, equivalent qualifications will be accepted. Full details of the University’s policy are available online.

Essential attributes:
• Experience of fundamental laboratory skills
• Competent in tissue culture
• Knowledge of biomedical science
• Good written and oral communication skills
• Strong motivation, with evidence of independent research skills relevant to the project
• Good time management

When applying for this position please quote Project ID SAS0017.