MRes in Innate Immune Evasion During Chlamydia Infection - Project ID SAS0022

Chlamydia trachomatis (C. trachomatis), is a common sexually transmitted infection throughout the world. Acute chlamydial infection is associated with inflammation, including an increase in cytokine expression and infiltration of inflammatory cells. While this can be protective, in many cases the Chlamydia is able to avoid the host immune response. In our laboratory, we are actively investigating the mechanisms through which Chlamydia evades host immunity, and using this knowledge to develop targeted treatments to infection.
The project will investigate how Chlamydia species are able to subvert the innate immune response with a view to informing the design of novel antimicrobial treatments. We will use a variety of in vitro models of Chlamydia infection to examine modulation of the inflammatory response of the host by these pathogens. This clinically relevant project has the potential to inform the development of new therapeutics for treating infections, and to impact upon the growing problem of antibiotic resistance in bacterial infections.

Academic qualifications
A first degree (at least a 2.1) ideally in immunology, infectious diseases, biomedical science, microbiology or another relevant discipline, with a good fundamental knowledge of innate immunity.

English language requirement
IELTS score must be at least 6.5 (with not less than 6.0 in each of the four components). Other, equivalent qualifications will be accepted. Full details of the University’s policy are available online.

Essential attributes:
• Experience of fundamental laboratory skills
• Competent in cell biology
• Knowledge of infectious disease
• Good written and oral communication skills
• Strong motivation, with evidence of independent research skills relevant to the project
• Good time management

Desirable attributes:
Molecular Biology and Cell Culture skills

When applying for this position please quote Project ID SAS 0022