Prof Anthony Green, Dr S Lovelock
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
The ability to rationally create an enzyme for any desired transformation is a long standing ambition within the field of biocatalysis. Within this project, we will employ state-of-the-art techniques in enzyme design, protein engineering and laboratory evolution to create efficient enzymes that promote the Morita-Baylis-Hillman reaction, a synthetically valuable transformation that has not been observed in nature to date. Crystallographic snapshots along the evolutionary trajectory will reveal the origins of increased catalytic efficiency, providing valuable insights to guide future generations of enzyme designs.
This is a highly interdisciplinary project at the cutting edge of enzyme design and engineering research, offering diverse training opportunities for a post-graduate student in a state-of-the-art multidisciplinary setting. The student will gain broad expertise in organic synthesis, molecular and structural biology, protein expression and purification, laboratory evolution, biochemical assays and computational biology. The student will spend a minimum of 3 months at GSK, gaining industrial experience in a world-leading pharmaceutical company.
Please select PhD Biological Chemistry on the application form.
http://www.chemistry.manchester.ac.uk/study/postgraduate/researchdegrees/howtoapply/
Contact for further Information
Anthony Green, [Email Address Removed]
Funding Notes
4 year BBSRC Industrial Case Partnership with GlaxoSmithKline (GSK). Funding will cover tuition fees, travel and an enhanced stipend (£17,777 in 2018). Open to UK/EU applicants. Please note, candidates from outside the UK must have resided in the UK for 3 years prior to commencing the PhD in order to be eligible. The PhD is expected to start in September 2018.
Applicants are expected to hold, or be about to obtain, a minimum upper second class undergraduate degree (or equivalent) in chemistry, biochemistry, biotechnology or related subject. A Masters degree and practical experience in a relevant subject area is desirable.
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