Manganese-catalysed C-H functionalization of aromatic molecules

C-H activation is en route to dramatically alter the way chemists make organic molecules with spectacular achievements over the last half decade. However, most advances have relied and still rely on the use of Pd-catalysts or other precious metals, with obvious sustainability issues: difficulty to apply to large scale synthesis, unreliability of the supply chain, large fluctuations on price, and the prospect of ‘running-out’ of the precious metal. Recently, Mn complexes have been shown to be able to mediate some C-H functionalisation processes in a ‘Pd-like’ manner, raising hopes that this could provide a robust alternative to current methods (Mn is the 3rd most abundant transition metal). However, lack of mechanistic understanding is hindering progress in the field, with most methods reported requiring harsh conditions (eg >100 °C) and showing low substrate scope. The successful candidate will apply state-of-the-art kinetic and organometallic mechanistic studies to the understanding of the current bottle-necks in Mn-catalysed C-H functionalisations. This knowledge will then be used to design new Mn-complexes capable of mild C-H activation methods with broadly applicable scope.

The student will receive training in organic synthesis, organometallic chemistry and in the design and development of complex multi-metallic catalytic cycles. Transferable skills such as reporting of results orally and in writing, time management, project planning and management will be developed.

Applicants are expected to hold, or about to obtain, a minimum upper second class undergraduate degree (or equivalent) in Chemistry subject area. A Masters degree in a relevant subject and/or experience is desirable.

Contact for further Information:
Prof. Igor Larrosa
[Email Address Removed]
https://personalpages.manchester.ac.uk/staff/igor.larrosa/index.html