Dietary modification of gut function and its role in human metabolic disease

Insulin resistance is a major characteristic of obesity and type II diabetes. A number of metabolically active tissues and several potential mechanisms have been implicated in the pathophysiology of insulin resistance, such as impaired glucose uptake by peripheral tissues, elevated hepatic glucose production, and impaired beta-cell function.

In addition to these well-described defects, there is emerging evidence to suggest that diet- and/or activity-induced changes in the gut microbiota might play an important role in the development of human metabolic disease, through a mechanism that is linked to increased gut permeability, metabolic endotoxaemia, and systemic low-grade inflammation.

This project will investigate diet-induced changes in gut barrier function, with a view to improving our understanding of the development of human metabolic disease. Applications are invited from potential self-funded students with a strong background in Nutrition/ Metabolism/ Biochemistry.

Entry requirements
Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in physiology, nutrition, biomedical science, biochemistry, exercise science or a related subject.

A relevant Master’s degree and/or experience in one or more of these topics, as well as experience running human nutrition trials, completing vascular measures and wet lab experience, will be an advantage.

All students must also meet the minimum English Language requirements: http://www.lboro.ac.uk/international/applicants/english/