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  Radiolabeling strategies for tracking nanoparticles in positron emission tomography


   Centre de Recherche du CHU de Québec

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  Prof Marc-Andre Fortin  No more applications being accepted

About the Project

Positron emission tomography is one of the most sensitive and quantitative techniques for tracking nanoparticles in vivo. This project aims at developing several methodologies for labeling organic, inorganic, and biological nanoparticles with PET radioisotopes of a half-life matching their bio distribution kinetics. The particles will be integrated in 3d-printed devices, and PET will be used to monitor and quantify the release of nanoparticles from the objects implanted in vivo (mouse model). This research project is at the crossroads of nanotechnology, biomedical imaging, and radiochemistry.

The laboratory for materials in medicine of CR-CHU de Québec is specialized in the development of nanoparticles for medical applications, in the development of 3d printing procedures and objects as medical implants, and in innovative in vivo tracking procedures in regenerative medicine. The laboratory is located in a state-of-the-art infrastructure (electron microscopy and other materials analysis techniques),hot room for radio labeling, chromatography equipment for nanoparticle purification, cell laboratories and small-animal imaging equipment installed in a modern animal facility (PET, MRI, CT, optical imaging).

The laboratory is seeking highly motivated individuals with background in chemistry, chemical engineering, or biochemistry, with demonstrated experience in radiochemistry, radio labeling, or radioisotope handling (MSc in radiochemistry preferable). The research team will also consider applications from students with experience in small-animal positron emission tomography.

Funding Notes

Project funded by a 4-year grant from the National Sciences and Engineering Research Council of Canada. Part of a pan-canadian project (polymers for drug delivery)

References

Please send 1 CV, letter of motivation, + 2 references to be contacted