Prof D Sheer, Dr A O'Loghlen
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Centre for Genomics & Child Health
Blizard Institute
Barts & the London School of Medicine & Dentistry
Queen Mary University of London
PhD studentship: Signalling mechanisms in children’s brain tumours
Applications are invited for a three-year PhD studentship to support a highly motivated candidate to study key signalling pathways in paediatric low-grade gliomas (pLGG). Applicants should have a good degree [minimum 2(i) or equivalent], with strong background knowledge of genetics, molecular biology, and pharmacology, as well as research experience in cancer therapeutics.
Most of the driver mutations in pLGG inappropriately activate the ERK/MAPK signalling pathway. Pilocytic astrocytomas (grade I LGG) exhibit indolent behaviour, which is thought to arise from oncogene-induced senescence. However, the mechanisms of senescence vs proliferation are not well-understood in this context. Grade II LGG include a heterogeneous group of tumour types, including diffusely infiltrating astrocytomas that are difficult to completely remove surgically. To develop optimal approaches for targeted therapy in pLGG and for clinical management, we need to identify the aberrant signals arising from the different genetic abnormalities and understand how they affect the phenotypic behaviour of the cells.
The aims of this project are to identify the molecular targets of the key genetic abnormalities in pLGG, understand how the signalling network is perturbed, and distinguish the signals that give rise to the senescent and proliferative phenotypes. Techniques used will include quantitative proteomic analyisis on glial cells, tumour cell models and tumour samples with activated MAPK pathway; mathematical modelling of the signal dynamics and responses to different mutations; and analysis of regulators of oncogene-induced senescence vs proliferation. The research will thus include both experimental and computational analyses.
Applications should include a personal statement, CV, and contact details of two referees.
Funding Notes
The studentship is fully funded for three years by Rosetrees Trust and will commence October 1, 2018. The student will receive a tax-free stipend per annum of £17,500.00, with a fee waiver at UK/EU levels.
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