Dr John Tregoning, Prof Matthew Fuchter
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Applications are invited for a BBSRC funded 1+3 year MRes:PhD studentship to work in the Mucosal Infection and Immunity group within the Faculty of Medicine of Imperial College London at the St Mary’s Campus in collaboration with Dr Matthew Fuchter, Department of Chemistry, Imperial College London.
We are seeking a highly motivated student to work on a BBSRC doctoral training program (DTP) funded research project. The aim of the project is to develop new antibiotics for anti-microbial resistant bacterial infection. We desperately need new antibiotics. Respiratory Bacteria need to utilise biochemicals in the airways to grow and we have shown that the airway glucose levels correlate with bacterial infection. Blocking bacterial glucose uptake may provide a novel antibiotic strategy. This is a multidisciplinary project between Microbiology and Chemistry investigating novel strategies to prevent infection with respiratory bacterial pathogens with high levels of antibiotic resistance (S. aureus, K. pneumoniae and P. aeruginosa).
The first part of the project will be to identify and confirm the role of P. aeruginosa genes in glucose uptake and metabolism. Having defined a role for specific genes, potential inhibitory compounds will be identified and tested. The most promising compounds will be subject to resynthesis and retesting, followed by synthesis of ‘near neighbours’ to determine early structure-activity relationships. These optimized compounds will then be tested.
Dr John Tregoning (http://www1.imperial.ac.uk/medicine/people/john.tregoning) and Dr Matthew Fuchter (https://www.imperial.ac.uk/people/m.fuchter) are the academic supervisors.
To apply: please send a single PDF document including a one-page cover letter discussing research interest and experiences, a two-page CV, a copy of transcripts, and contact information of two references to Dr John Tregoning ([Email Address Removed]) with subject line “BBSRC_DTP_PhD_App” before the closing date of 21st May 2018.
Funding Notes
The studentship is open to UK and EU nationals who have been resident in the UK for at least 3 years. It includes payment of UK/EU fees and an annual stipend of £16,700 for 4 years starting 1st October 2018.
Applicants must have a first or upper second class BSc degree from a UK University, or the overseas equivalent, in a relevant area of biochemistry, chemistry or microbiology. Experience in molecular biology is a major advantage. Applicants must also meet Imperial College’s English language requirements see: http://www3.imperial.ac.uk/registry/admissions/pgenglish
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