Dr Kofi Asare-Addo
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Applications are invited for one of 12 fully funded EPSRC PhD studentships in the area of Materials Science at the University of Huddersfield. Applicants should be of outstanding quality and exceptionally motivated.
Please note that there are more projects than funded studentships and therefore this is a competitive application process that will include an interview. After the interview the 12 most outstanding applicants will be offered a studentship.
A compounds selection and its eventual development into a drug product is expensive (estimated to be approximately $1.8 billion) and time consuming. Roughly 1 out of every 5-10,000 compounds successfully becomes a drug product. To reduce costs, there have been advances in the compound screening processes over the years (computer-based drug design programs and combinatorial chemistry). Despite these advances, there is still a knowledge gap as to how compounds behave from an imaging perspective and how these behaviours can be exploited to identify ideal candidates for drug products. This project will use the novel Surface Dissolution Imaging Apparatus (SDI2) and the AliconaTM Focus Variation surface metrology system for material surface form and texture characterization to study pharmaceutical compound behaviour.
Understanding the behaviour of pharmaceutical materials is of great interest to pharmaceutical companies. The field of visualising and understanding pharmaceutical compound is relatively new and as such there are huge gaps in current knowledge. Preliminary work in our lab using surface dissolution imaging and a Focus Variation instrument, showed the wave developments to be caused by excess material on the rim of the surfaces and in imprints of the die machining marks on the compact’s surfaces. This could potentially give inflated IDR values. This project will be looking to exploit the full capabilities the SDI2 instrumentation to allow us to develop methodology and build a robust model that allows prediction of IDRs based on surface topography measurements.
Supervisory team: Main Supervisor: Dr Kofi Asare-Addo (email: [Email Address Removed])
Co-Supervisor: Dr Karl Walton and Professor Liam Blunt
To apply for this Studentship:
• complete the Materials Science PhD Studentship Application Form - https://research.hud.ac.uk/media/assets/document/research/Material_studentship_application_form.docx
• provide a current detailed CV, identifying any research employment or experience and, where applicable, details of research conference presentations or publications
• provide copies of transcripts and certificates of all relevant academic and/or any professional qualifications
• provide references from two people
• send all of the above to [Email Address Removed] and [Email Address Removed]
• Submit an application using the University’s online application portal: https://pgr-onlineapps.hud.ac.uk indicating Dr Asare-Addo as supervisor and the School as Applied Sciences. There is no requirement for a research proposal.
The closing date for the receipt of completed applications is 30 June 2018 (23.59, BST).
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