About the Project
General objectives of the CaReSyAn project
Successfully combating a complex disease requires multi-disciplinary and methodically well trained scientists. CaReSyAn strives to accomplish exactly this: we will train scientists to successfully integrate proteomics, clinical, experimental and bioinformatics analyses to enhance the understanding, diagnosis and therapy of the cardiorenal syndrome (CRS). CRS comprises disorders of the heart, vessels and kidneys, including the increased development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). With ~45% of all deaths in CKD patients caused by CVD, the socio-economic burden of CRS is extremely high.
For more information: https://www.caresyan.eu/
A fixed-term for 3 years PhD student position is open at Mosaiques Diagnostics, Hannover, Germany. The successful candidate will work at the interface between kidney and cardiovascular disease as part of CaReSyAn H2020-MSCA-ITN-2017 (project 764474).
Mosaiques Diagnostics (MOS) is the leading specialist in clinical proteome and CE-MS analysis, currently the most advanced technology to identify disease-specific polypeptide biomarkers in body fluids. Mosaiques Diagnostics has published more than 200 papers in leading journals and has also led the consortium that defined standards for clinical proteome analysis. Main research activities are identification of urinary biomarkers for human diseases; sequencing of peptide biomarkers, identification of post translational modifications, development of software to analyse multidimensional data; and establishment of proteome maps of human body fluids. Mosaiques’ proprietary technology enables reproducible analysis and evaluation of urine samples with mass spectrometry in a short time, based on a unique and proprietary database of proteins and peptides in human urine from over 40.000 participants. See also http://mosaiquesdiagnostics.com
Specific Information for the position
The successful candidate will study CRS pathology with a focus on urinary peptide biomarkers that may enable diagnosis, prognosis or prediction of response. The specific project rests on previous work where urinary biomarkers for kidney and cardiovascular disease were identified and validated, in part in large studies. The student will investigate urinary peptides in samples from large cohorts (between 100 and 1000) employing CE-MS, which is available as routine technology platform. Special emphasis will be on identification of biomarkers significantly associated with progression in disease, and on linking the biomarkers to disease pathophysiology. For more information, we refer to e.g. Htun NM, et al. Prediction of acute coronary syndromes by urinary proteome analysis. PLoS. One., 12: e0172036.; Pontillo C, et al. Prediction of chronic kidney disease stage 3 by CKD273, a urinary proteomic biomarker. Kidney International Reports, 2(6):1066-1075.
Additional Information
Please send your application to [Email Address Removed] until May 15th, 2018
Requirements
Offer Requirements
REQUIRED EDUCATION LEVEL
Biological sciences: Master Degree or equivalent
REQUIRED LANGUAGES
ENGLISH: Excellent
Skills/Qualifications
The candidates must have a MSc. Degree, ideally in biology or related fields, be fluent in English and have an excellent university track record.
Specific Requirements
According to the EU rules for the ITN projects, the recruited researchers must comply with the following conditions:
- are - at the date of recruitment - early-stage researchers (i.e. NOT have a doctoral degree AND be in the first 4 years (full-time equivalent research experience) of their research career)
- be employed for at least 3 months and up to 36 months.
- be employed full-time, unless the Agency has approved a part-time employment for personal or family reasons
- work exclusively on the research training activities
- must comply with the following mobility rule: not have resided in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date (and not have carried out their main activity (work, studies, etc.) in that country) — unless as part of a procedure for obtaining refugee status under the Geneva Convention. For beneficiaries that are international European interest organisations or international organisations: not have spent with the beneficiary more than 12 months in the 3 years immediately before the recruitment date
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