ICIQ_C2-21: Catalytic C-H Amination for Innovative Alkaloid Total Synthesis

This project will cover the following aspects: Homogeneous Catalysis, Natural Product Synthesis, Oxidation, Amination

This project aims to develop innovative C-H amination reactions of alkanes, which have no biosynthetic precedence. They serve as novel entries into alkaloid structures of higher complexity. The topic comprises both the development of such new synthetic methodology and the contribution to the total synthesis of molecules with profound biological or medicinal interest. These strategic approaches are characterized by their de novo retrosynthetic analysis proceeding through a significantly shorter number of steps than usually employed. They will also serve to generate libraries of natural product derivatives for biomedical screening. This latter aspect can be pursued within national and international collaborations.

Eligibility Criteria
To be admitted to the review process, candidates must comply with the following eligibility criteria:

• Presenting complete applications including all requested compulsory information and documentation.

• Having not spent more than 12 months of the prior 36 months in Spain, at the time of the call deadline. You will be required to confirm your compliance through a self-declaration.

• Hold a University degree (by the time of enrollment in the PhD program) that would qualify the applicant to enter one of the PhD programmes recognized by the BIST research centers. These have formal agreements with the major Catalan Universities (UB, UAB, UPC, URV, and UPF) whereby BIST senior researchers (generally of professorial rank and enjoying international recognition) are accredited to supervise PhD students, who do their research at BIST research centres and obtain their degree from the corresponding university. Please provide evidence when you apply (e.g. scanned copy of your degree or similar).

• At the time of the call deadline, be in the first 4 years of your scientific post gradual career (full-time equivalent research experience). In case your University degree was longer ago than 4 years, you will need to provide documental evidence for complying with this criteria.

• Having not been awarded yet a PhD degree.