About the Project
This project will cover the following aspects: Transcription, intrinsically disordered proteins, liquid liquid phase separation, drug discovery, nuclear magnetic resonance, molecular simulations.
We are interested in understanding the role that liquid phase separation processes involving transcription factors plays in transcriptional regulation. We are also interested in interfering with those processes for cancer therapy.
A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.
Eligibility Criteria
To be admitted to the review process, candidates must comply with the following eligibility criteria:
• Presenting complete applications including all requested compulsory information and documentation.
• Having not spent more than 12 months of the prior 36 months in Spain, at the time of the call deadline. You will be required to confirm your compliance through a self-declaration.
• Hold a University degree (by the time of enrollment in the PhD program) that would qualify the applicant to enter one of the PhD programmes recognized by the BIST research centers. These have formal agreements with the major Catalan Universities (UB, UAB, UPC, URV, and UPF) whereby BIST senior researchers (generally of professorial rank and enjoying international recognition) are accredited to supervise PhD students, who do their research at BIST research centres and obtain their degree from the corresponding university. Please provide evidence when you apply (e.g. scanned copy of your degree or similar).
• At the time of the call deadline, be in the first 4 years of your scientific post gradual career (full-time equivalent research experience). In case your University degree was longer ago than 4 years, you will need to provide documental evidence for complying with this criteria.
• Having not been awarded yet a PhD degree.