This project is no longer listed in the FindAPhD
database and may not be available.
The position is available from September 2018, funded by an ERC Advanced Grant which covers tuition fees and stipend for 4 years Applications are invited from UK/EU nationals. Candidates from outside the UK must have resided in the UK for 3 years prior to commencing the PhD to be eligible to apply.
Applicants are expected to hold, or be about to obtain, a minimum upper second class undergraduate degree (or equivalent) in chemistry, biochemistry or a related science. A Masters degree in a relevant subject and/or experience in bioinformatics or biocatalysis is desirable.
France, Scott P; Hepworth, Lorna J; Turner, Nicholas J; Flitsch, Sabine L; “Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways.” ACS Catal., 2017, 7(1), 710-724. DOI: 10.1021/acscatal.6b02979
France, Scott P.; Hussain, Shahed; Hill, Andrew M.; Hepworth, Lorna J.; Howard, Roger M.; Mulholland, Keith R.; Flitsch, Sabine L.; Turner, Nicholas J. “One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts”. ACS Catalysis (2016), 6(6), 3753-3759. DOI:10.1021/acscatal.6b00855
Hepworth, Lorna; France, Scott; Hussain, Shahed; Both, Peter; Turner, Nicholas; Flitsch, Sabine. De Novo Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines.” ACS Catalysis, 2017, 7, 2920-2925. DOI: 10.1021/acscatal.7b00513
Sardzik, Robert; Green, Anthony P.; Laurent, Nicolas; Both, Peter; Fontana, Carolina; Voglmeir, Josef; Weissenborn, Martin J.; Haddoub, Rose; Grassi, Paola; Haslam, Stuart M.; Widmalm, Goran; Flitsch, Sabine L. “Chemoenzymatic Synthesis of O-Mannosylpeptides in Solution and on Solid Phase” JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 134(10); 4521 – 4524. DOI 10.1021/ja211861m – MAR 14 2012
Both, H. Busch, P. Kelly, F. G. Mutti, N. J. Turner, S. L. Flitsch, Sabine J. “Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions”. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION., 55; 1511 – 1513.DOI: 10.1002/anie.201510028– JAN 22 2016