Designing Bioelectronic Materials for the Heart

Cardiovascular diseases are the number one cause of death worldwide. There are few therapeutic options available following myocardial infarct as cardiac tissues possess relatively low reparative and regenerative capabilities, imposing a global socioeconomic burden. Biomaterial-based strategies are being sought in the search for a much needed, innovative and timely solution. Polymer-based electroactive biomaterials have been traditionally hindered in cardiac applications because of issues concerning their biocompatibility, ability to withstand the strenuous and dynamic environment of cardiac tissues, and incapability of influencing cardiac cells following infarct.

Within this Plastic Electronics CDT studentship led by Profs Molly Stevens and Martin Heeney, we will use powerful in-house designed synthetic approaches to end-functionalised, homogenous, and electroactive conjugated oligomers, to form electroresponsive cardiac scaffolds. These materials will be formulated into the first electroactive auxetic patch capable of withstanding the native physiological cardiac environment. The unique patterning of the patch enables extension in both directions under strain to match the motion of the heart. It is envisaged that this work will have a major impact on clinical interventions towards the treatment of cardiac disease.

The ideal student has a strong background in chemistry, engineering or Biomaterials/life sciences, with a track record of undertaking interdisciplinary research. Pro-active and enthusiastic students are greatly recommended to apply. The position must start by 1 October 2018.

The Stevens Group (http://www.stevensgroup.org) has been recognised by over 20 awards.

For more information and to first check suitability, please contact Prof Molly Stevens: [Email Address Removed]