Dr Andrejs Braun
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
We are pleased to offer the below fully funded studentship, starting in September 2018.
Our Institute has an international reputation for cancer research, with world renowned experts in the field. Our PhD training programme aims to develop a cohort of scientists equipped both intellectually and technically to conduct the highest quality research on cancer.
Our research degrees are supplemented by a comprehensive support programme, providing training in a wide range of biomedical laboratory methods and other vital transferable skills.
You will be based at the beautiful Charterhouse Square campus in the heart of London.
Project Outline:
The nuclear periphery is a unique compartment comprised of inner nuclear membrane proteins and nuclear lamina. Previously, genome-wide and cytological studies revealed the regulatory role for some of these nuclear proteins in higher level genome organisation and gene regulation. In particular, Lamina Associated Domains (LADs) were identified at the nuclear periphery as large, transcriptionally silent, gene-poor domains associated with Lamin B1. More recent studies have revealed an important role of LADs in the regulation of gene expression. Moreover, developmentally regulated genes were found to be specifically enriched in these domains, leading to the theory that LADs are regulated as facultative heterochromatin compartments during development.
We have recently demonstrated that Lamin B1, a component of the nuclear envelope and a key regulator of LAD dynamics, is a suppressor of somatic hypermutation in B cells (Klymenko et al., 2018). Moreover, nuclear Lamin B1 was found to be decreased in the majority of B cell-derived lymphomas, and low LMNB1 expression, being associated with multiple cytogenetic abnormalities, was a strong negative prognostic factor for both PFS and OS in CLL (Klymenko et al., 2018).
The successful candidate will apply various state-of-the-art imaging and genomics techniques to dissect the mechanisms of lamina regulation in normal and malignant B cells. Due to the anticipated volume of NexGen sequencing data, those candidates with experience in bioinformatical analysis of somatic mutations are particularly welcome.
For more information, please see our website:
https://www.bci.qmul.ac.uk/en/study-with-us/postgraduate-research/bci-funded-phd-studentships-6-positions
Funding Notes
The studentship includes the following funding for 3 years:
- A tax free annual stipend of £21,000
- Tuition Fees at the Home/EU rate*
- Project consumables
*If you are considered an overseas student for fee purposes, you are welcome to apply for these studentships, however you will be required to cover the difference in tuition fees.
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