Dr R Grose
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
We are pleased to offer the below fully funded studentship, starting in September 2018.
Our Institute has an international reputation for cancer research, with world renowned experts in the field. Our PhD training programme aims to develop a cohort of scientists equipped both intellectually and technically to conduct the highest quality research on cancer.
Our research degrees are supplemented by a comprehensive support programme, providing training in a wide range of biomedical laboratory methods and other vital transferable skills.
You will be based at the beautiful Charterhouse Square campus in the heart of London.
Project Outline:
Glioblastoma multiforme (GBM) represents the most common form of aggressive primary brain tumour in adults, and has a dismal prognosis, with 5-year survival rates of less than 5%. EGFR amplifications/mutations occur in approximately 50% of GBM, making EGFR an attractive therapeutic target for tyrosine kinase inhibitor (TKI) therapy. However, attempts to treat patients with EGFR-targeted therapies have been severely undermined by the speed with which tumours evolve resistance.
Having identified a novel resistance pathway to TKI targeted therapy in breast and endometrial cancer (Fearon et al. 2018. Cell Reports: 22, 2469-2481), whereby PI3K signalling allows cancer cells to establish a drug resistant population, our current studies are building on this to try and develop novel therapeutic strategies to overcome drug resistance. This project will use a combination of screening approaches (involving CRISPR, RNAi and chemical libraries) to identify and target resistance pathways in GBM cell lines and primary cells. Functional studies will be performed to validate potential targets, using 3D modelling and xenograft approaches, alongside interrogation of clinical samples.
This project is ideally suited to an ambitious student with a keen interest in translational cancer research. Informal queries regarding the project are welcomed – please e-mail to arrange a meeting ([Email Address Removed]).
For more information, please see our website:
https://www.bci.qmul.ac.uk/en/study-with-us/postgraduate-research/bci-funded-phd-studentships-6-positions
Funding Notes
The studentship includes the following funding for 3 years:
- A tax free annual stipend of £21,000
- Tuition Fees at the Home/EU rate*
- Project consumables
*If you are considered an overseas student for fee purposes, you are welcome to apply for these studentships, however you will be required to cover the difference in tuition fees.
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