Assoc Prof P Bourgine
No more applications being accepted
About the Project
The lab: The successful candidates will be part of the novel laboratory for Cell, Tissue and Organ engineering. The laboratory aims at deciphering the cellular & molecular mechanisms occurring during phases of bone formation/repair. Using state-of-the-art 3D culture systems, death-inducible human mesenchymal lines and tissue engineering protocols, we focus on studying processes of cartilage/bone/bone marrow establishment in human(ized) contexts. Compiled knowledge will be used for the design of cell-based but cell-free extracellular matrices, to be used as smart-materials for skeletal repair. As such, the lab covers both fundamental and translation research aspects. More information available on our website: www.bourginelab.com
Project: The candidate will exploit human mesenchymal lines capable of generating human Bone Organ in mice. This is achieved by in vitro engineering of cartilage tissue, undergoing remodelling into bone and bone marrow in vivo. This recapitulation of the endochondral pathway will be used as a platform/model to study processes of bone formation/repair. Precisely, the candidate is expected to help decoding the cellular events associated with the formation of human Bone Organ. This will include the quantitative identification of endothelial, osteoprogenitor and immune cell populations’ recruited upon tissue transplantation, and the assessment of their role in the remodelling process.
Ideal profile: You are finishing (or just finished) your Master degree in Biology/Biotechnology and you are strongly interested in academic research. You are a dynamic person with a strong and healthy ambition to discover.
Desirable skills: Good speaking/writing English levels, experience in molecular biology, cell culture and flow cytometry/immunostainings are strong assets. The capacity to work with animals is mandatory.
Working Pattern: Full time
Faculty: Faculty of Medicine, University of Lund
Starting Date: from October 2018
Funding Notes
The position is funded by the Wallenberg Centre for Molecular Medicine (WCMM), Focusing on regenerative medicine (regeneration, replacement and repair), the WCMM is a part of a national effort to reposition Sweden as a world-leading life science nation.
The position consists in a 4 years contract.
References
Bourgine et al.; Engineering Human Bone Marrow Proxies, Cell Stem Cell - 2018
Bourgine et al.; In vitro biomimetic engineering of a human hematopoietic niche with functional properties, PNAS - 2018
Bourgine et al.; Osteoinductivity of engineered cartilaginous templates devitalized by inducible apoptosis, PNAS - 2014
Bourgine et al.; Tissue decellularization by activation of programmed cell death, Biomaterials - 2013
Continue with Facebook
