We have 57 PhD Research Projects PhD Projects, Programmes & Scholarships in Jordanstown

USP17 is over-expressed in a range of primary tumours including NSCLC, breast, colorectal, cervical, ovarian and osteosarcoma and its depletion has been shown to block the growth of cells from all these cancer types, as well as the migration of a range of cancer cells (NSCLC, breast, ovarian, osteosarcoma). . Read more

Supervisor: Dr J Burrows

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of carers in medicines management for people living with dementia

Queen’s University Belfast School of Pharmacy

It is estimated that there are close to 50 million people living with dementia worldwide, and this number is estimated to double every 20 years. Read more

Supervisors: Dr H Barry, Prof C Hughes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments

Queen’s University Belfast School of Pharmacy

Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more

Supervisors: Dr I Tikhonova, Dr B Plouffe

Year round applications PhD Research Project Self-Funded PhD Students Only

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High throughput exploration of the design space for antifungal nanocarrier development

Queen’s University Belfast School of Pharmacy

Fungal and bacterial infections contribute to over 7 million deaths yearly, affecting over 300 million people globally (GAFFI). Read more

Supervisor: Dr J Tian

Year round applications PhD Research Project Self-Funded PhD Students Only

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A systematic screening tool for nanocarrier design and efficient drug delivery against biological barriers.

Queen’s University Belfast School of Pharmacy

Encapsulation of APIs in a liposome can dramatically alter the distribution by controlling the release to normal tissue while facilitating the accumulation to the site of inflammation. Read more

Supervisor: Dr J Tian

Year round applications PhD Research Project Self-Funded PhD Students Only

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Designing and evaluating novel nanotherapeutics to enhance the effectiveness of radiotherapy in the treatment of solid cancers.

Queen’s University Belfast School of Pharmacy

One in two cancer patients will receive radiotherapy as part of their treatment. For patients with a localised cancer diagnosis effective radiotherapy represents the best chance of a curative outcome, however, is not without risk. Read more

Supervisor: Dr J Coulter

Year round applications PhD Research Project Self-Funded PhD Students Only

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Synthetic Protein-Transporters for Enhanced Transduction Activity

Queen’s University Belfast School of Pharmacy

Intracellular protein delivery is key to probing important cellular processes and developing advanced biotherapeutics. However, protein trafficking into the cell, and more specifically to the cytosol remains a significant challenge. Read more

Supervisor: Dr S Carmali

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigation of novel protease-antiprotease imbalances associated with cystic fibrosis and the effect of CFTR correction.

Queen’s University Belfast School of Pharmacy

Cystic fibrosis (CF) is a progressive life-limiting airways disease that affects over 162,000 people worldwide. Read more

Supervisor: Prof L Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Selective targeting of furin for the treatment of fibrotic lung disease.

Queen’s University Belfast School of Pharmacy

Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more

Supervisor: Prof L Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Developing biodegradable long acting drug delivery systems for the treatment of chronic conditions

Queen’s University Belfast School of Pharmacy

Non-adherence to treatment costs the NHS more than £500M each year. Adherence is especially important when treating patients with chronic conditions that require lifetime pharmacological treatment, such as schizophrenia, Parkinson’s disease, HIV and Alzheimer’s disease. Read more

Supervisors: Dr E Larraneta, Prof R Donnelly

Year round applications PhD Research Project Self-Funded PhD Students Only

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Peptide-based nanoparticles for brain targeted gene delivery.

Queen’s University Belfast School of Pharmacy

Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases and cancer. Delivery into the brain is hampered by the blood-brain barrier (BBB), which limits the efficacy of both conventional and novel therapies at the target site. Read more

Supervisors: Dr E McErlean, Prof H McCarthy

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genetic Engineering of Immune Effector Cells for CAR therapies using a Peptide Technology

Queen’s University Belfast School of Pharmacy

Chimeric antigen receptor (CAR)-T therapies have demonstrated remarkable treatment outcomes and several CAR-T therapies now approved for treatment of haematological malignancies. Read more

Supervisors: Dr E McErlean, Prof H McCarthy

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterising biofilm-forming microbes in endotracheal tubes to direct a new strategy for preventing ventilator-associated pneumonia in critically ill adults

Queen’s University Belfast School of Pharmacy

Endotracheal tubes (ETTs) are employed for invasive mechanical ventilation of critically ill patients with acute respiratory failure. Read more

Supervisors: Dr L Sherrard, Dr M Wylie

Year round applications PhD Research Project Self-Funded PhD Students Only

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Developing novel therapeutic strategies to better treat Triple Negative Breast Cancer

Queen’s University Belfast School of Pharmacy

One in two people will develop cancer in their lifetime and it is a leading cause of death. While significant progress has been made in the treatment of some cancers, there still remain some forms of the disease with limited treatment options and poor outcome. . Read more

Supervisor: Dr N Buckley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Self-regulating, self-cleaning biomaterials

Queen’s University Belfast School of Pharmacy

A major problem associated with medical devices is infection. With infection rates of approaching 100% in some devices, ways to prevent formation of bacterial biofilm on medical device surfaces are urgently required. Read more

Supervisors: Prof C McCoy, Dr M Wylie

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 57 PhD Research Projects PhD Projects, Programmes & Scholarships in Jordanstown

PhD Research Projects PhD Projects, Programmes & Scholarships in Jordanstown

We have 57 PhD Research Projects PhD Projects, Programmes & Scholarships in Jordanstown

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