Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in London

We have 126 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in London

Multimodal Artificial Intelligence for the Detection and stratification of Necrotising Enterocolitis in premature born infants (MAIDNEC)

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

Necrotising Enterocolitis (NEC) is a severe gastrointestinal inflammatory condition affecting neonates, most commonly premature infants although up to 25% is observed among full-term babies1. Read more

Supervisors: Dr S Eaton, Dr E Mazomenos

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Precision Diagnosis for Congenital Anomalies – using AI & leveraging multimodality data to help counsel parents appropriately in rare diseases.

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

Skeletal dysplasias are a heterogenous group of congenital bone and cartilage disorders with genetic etiology. There are currently 461 recognised diseases that fall into this category. Read more

Supervisors: Dr S Shelmerdine, Prof I Drobnjak, Prof O Arthurs

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Using artificial intelligence and machine learning techniques to improve diagnosis and predict outcomes in children with heart muscle disease.

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

Paediatric cardiomyopathies, or heart muscle diseases, are a group of rare and heterogeneous conditions with highly variable outcomes. Read more

Supervisors: Dr JPK Kaski, Dr G Norrish

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Disease modelling to understand long-term progression and treatment response in Spinal Muscular Atrophy and Duchenne Muscular Dystrophy.

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

This project addresses the urgent medical need to collect and analyse big data sources. on the natural history disease progression of children with Spinal Muscular Atrophy (SMA) and Duchenne Muscular Dystrophy (DMD). Read more

Supervisors: Dr G Baranello, Dr D Ridout

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Health and education outcomes of children with Sickle Cell Disease in England

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

SCD is a serious, life-long condition that can cause anaemia, increased infection risk, and pain.1 Around 300 babies are born with SCD annually in the UK. Read more

Supervisors: Dr R Knowles, Prof P Hardelid

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Health outcomes of children with rare or complex conditions and their families: a longitudinal cohort study using linked primary and secondary healthcare data in England

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

Rare or complex conditions (RCCs), such as major congenital anomalies or inherited conditions that are screened for in newborns, have serious health, functional and social consequences for affected individuals. Read more

Supervisors: Dr AZ Zylbersztejn, Dr J Tan, Prof MCB Cortina Borja

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Health and development outcomes and their interaction for children with chronic liver disease: a population-based cohort using novel linkage between health and education records

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

Each year in the UK, 400 children are diagnosed with chronic liver disease (CLD), with a fifth requiring liver transplantation at some stage. Read more

Supervisors: Prof KH Harron, Dr AZ Zylbersztejn

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Advancing translational cell therapy for Hirschsprung disease

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Clinical disorders characterised by neuronal loss or dysfunction in the gastrointestinal tract remain some of the most challenging to manage, with considerable morbidity and mortality and very limited treatments. Read more

Supervisors: Dr C McCann, Prof P De Coppi

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Optogenetic sculpting of next-generation organoids for disease modelling of congenital malformations including spina bifida

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

The ability to generate human induced pluripotent stem cells (iPSC) from adult cell types has revolutionised regenerative medicine research. Read more

Supervisors: Dr G Galea, Prof J Sowden

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Vascularising human mini-brains in a dish

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Blood vessels play a pivotal role in brain development and function. They promote tissue growth and survival by supplying nutrients and oxygen to surrounding tissues, signals to progenitor populations, as well as guiding neuronal migration. Read more

Supervisors: Dr PA Alexandre, Prof D Long

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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AI-assisted diagnosis, surgical planning & implant design for craniofacial patient care

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Craniofacial diseases, particularly in craniosynostosis cases, present significant challenges in diagnosis and treatment. Read more

Supervisors: Dr S Schievano, Prof O Jeelani

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Role of mechanical signals in a 3D human model of alveolar differentiation

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more

Supervisors: Dr S Loukogeorgakis, Dr F Michielin, Prof P De Coppi

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Treatment and biomarker development for inherited manganese transporter defects using cell models of SLC30A10 deficiency

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Manganese is essential to human health and development. However, excess manganese is neurotoxic causing manganism, a neurodegenerative disorder characterised by dystonia-parkinsonism. Read more

Supervisors: Dr K Tuschl, Dr P Mills, Dr WH Heywood

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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A Patient-derived 3D humanized model of ADCY5-related disease to accelerate therapeutic approaches for patients

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

ADCY5-related disease is a genetic disorder caused by mutations in the ADCY5 gene, which encodes for the isoform 5 of adenylyl cyclase (ADCY5)1. Read more

Supervisors: Dr S Barral, Dr M Kurian, Dr HZ Zhou

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Developing an ADAR-mediated RNA editing therapy for treatment of Duchenne Muscular Dystrophy

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder affecting 1:5000 boys at birth (1). DMD is caused by mutations in Dystrophin gene, with around 10% of the cases caused by nonsense mutations (2,3). Read more

Supervisors: Dr HZ Zhou, Dr J Meng, Prof F Muntoni

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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We have 126 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in London

Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in London

We have 126 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in London

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