Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

We have 134 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

Full exploitation of amyloid PET-MR data for dementia research

The University of Manchester Faculty of Biology, Medicine and Health

Simultaneous PET-MR data acquisition using amyloid radiotracers has utility for future clinical studies such as the development of novel therapeutic interventions for dementia. Read more

Supervisors: Dr M Asselin, Dr J Matthews, Dr L Parkes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Determining how immune responses are regulated in the lung and gut by the local environment

The University of Manchester Faculty of Biology, Medicine and Health

The immune system must respond quickly to infection but must also be tightly regulated so it ignores harmless substances and our own tissues. Read more

Supervisors: Prof M Travis, Prof R K Grencis, Prof D Thornton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Circadian mechanisms in psoriasis: therapeutic opportunities

The University of Manchester Faculty of Biology, Medicine and Health

Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more

Supervisors: Dr H Young, Dr I Iqbal, Prof D Ray

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating monogenic disorders of the protein synthesis machinery

The University of Manchester Faculty of Biology, Medicine and Health

Translation of mRNA into proteins is a critical cellular biological process. We recently described a novel human disorder, now called Faundes-Banka Syndrome (FABAS), caused by heterozygous variants in EIF5A1 that encodes a translation factor. Read more

Supervisors: Dr P Kasher, Dr S Banka, Prof G D Pavitt

Year round applications PhD Research Project Self-Funded PhD Students Only

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Mapping CD4+ T cell fate decisions and functional coordination within tissues during infection

The University of Manchester Faculty of Biology, Medicine and Health

CD4+ T cells are essential components of the immune system, orchestrating protection against infection. Read more

Supervisors: Dr K Couper, Prof DD Dyer

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health

T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more

Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The University of Manchester Faculty of Biology, Medicine and Health

The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more

Supervisors: Dr M Lagator, Prof M Rattray

Year round applications PhD Research Project Self-Funded PhD Students Only

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Delineating the IRF6 regulatory network driving periderm formation and function

The University of Manchester Faculty of Biology, Medicine and Health

During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more

Supervisors: Prof M Dixon, Dr J Dixon

Year round applications PhD Research Project Self-Funded PhD Students Only

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Diagnostics for FMF patients and carrier survival in pandemics

The University of Manchester Faculty of Biology, Medicine and Health

Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more

Supervisors: Dr P Arkwright, Dr G Lopez-Castejon, Dr J Cavet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the mechanistic basis of Aspergillus fumigatus and Non-tuberculous mycobacteria coinfection

The University of Manchester Faculty of Biology, Medicine and Health

Respiratory infections caused by bacteria, fungi and viruses are a global cause of death according to the WHO. Respiratory coinfections are on the rise and in general linked with poor patient outcomes. Read more

Supervisors: Dr S Gago, Dr CK Kosmidis, Prof L Tabernero

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Supervisors: Prof R O'Keefe, Prof B Newman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

The University of Manchester Faculty of Biology, Medicine and Health

Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more

Supervisors: Dr G. Morris, Dr R Wykes, Prof R Baines

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the protective effects of a commensal bacterial strain in skin barrier function and protection from disease

The University of Manchester Faculty of Biology, Medicine and Health

Maintaining a healthy skin barrier is vital for our health. In response to skin wounding, we have a well-orchestrated immune response that heals the breach. Read more

Supervisors: Prof S Cruickshank, Prof A McBain, Dr R Unwin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genotypic and phenotypic markers of resistance in Aspergillus fumigatus and their impact on outcomes in chronic pulmonary aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

Chronic pulmonary aspergillosis (CPA) is a progressive infection affecting patients with chronic lung disease. It significantly affects quality of life and mortality. Read more

Supervisors: Dr CK Kosmidis, Dr M Bromley, Dr R Richardson, Dr M Bottery, Prof T Hussell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Dysfunctional antifungal potency of the respiratory mucosa in COPD

The University of Manchester Faculty of Biology, Medicine and Health

Inhalation of Aspergillus fumigatus spores cause >3,000,000 chronic and >200,000 invasive diseases annually worldwide. Invasive aspergillosis carries a 50% mortality rate overall, but mortality rate approaches 100% if diagnosis is delayed or missed and it is >75% in certain cohorts of patients, such as COPD sufferers. Read more

Supervisors: Dr M Bertuzzi, Dr J.H Herbert, Dr S Gago

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 134 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

We have 134 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

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