Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Sheffield

We have 67 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Sheffield

Engineering Virus-Like Particles for Next-Generation Vaccine Manufacturing

University of Sheffield Department of Chemical & Biological Engineering

Virus-like particles (VLPs) are structures typically composed of viral structural proteins that self-assemble into virus-like structures. Read more

Supervisors: Dr K Tee, Prof TS Wong, Dr C Evans

30 April 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Microbial Community Dynamics and Biocide Susceptibility Profiles in Chronic Wound Biofilms

Sheffield Hallam University Biomolecular Sciences Research Centre

The Industry and Innovation Research Institute (I2Ri) draws on talents, expertise and facilities across Sheffield Hallam University. Read more

Supervisors: Dr S Forbes, Dr KM Miller, Dr N Aberdein, Dr F Clegg

10 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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The role of eIF2Bα in the response to Integrated Stress Response (ISR) modulation in cancer

Sheffield Hallam University Biomolecular Sciences Research Centre

The Industry and Innovation Research Institute (I2Ri) draws on talents, expertise and facilities across Sheffield Hallam University. Read more

Supervisors: Dr E Allen, Dr SC Campbell

10 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Untangling how Shelterin safeguards telomere structure and stability - one molecule at a time

University of Sheffield School of Biosciences

Background. Telomeres solve two problems with linear chromosomes. the end-replication problem, DNA loss from the end of chromosomes every replication cycle; and the end-protection problem, protection of the chromosome ends to prevent chromosome fusions. Read more

Supervisors: Dr M Newton, Dr A Pyne

3 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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How does glycolysis influence the oral environment during caries and periodontitis?

University of Sheffield School of Clinical Dentistry

Glycolysis plays a pivotal role during energy metabolism and cellular responses in oral health and pathology. It is a crucial metabolic pathway for energy production, especially in inflammation or infection scenario, that is essential for maintaining tissue integrity and function in the gingiva and dental pulp. Read more

Supervisors: Dr C M Neves, Prof G Stafford

31 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Targeting dormant cancer cells in myeloma

University of Sheffield School of Medicine and Population Health

Multiple myeloma is the second most common blood cancer and remains essentially incurable. Chemotherapy is effective at reducing tumour and extends survival, but it never fully eradicates disease, so patients face inevitable relapse. Read more

Supervisors: Dr A Green, Prof S El-Khamisy

31 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Unravelling the role of P4HB in skeletal development: towards treatment of heritable bone fragility

University of Sheffield School of Medicine and Population Health

Osteogenesis Imperfecta (OI) affects 1 in 15-20,000 live births and results in a childhood with frequent fractures, reduced mobility and joint problems. Read more

Supervisor: Dr M Balasubramanian

Year round applications PhD Research Project Self-Funded PhD Students Only

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Precision Therapy for NBAS-related disorder

University of Sheffield School of Medicine and Population Health

It is very well recognised that rare diseases offer the potential to uncover new information about mechanisms underlying a range of phenotypes. Read more

Supervisor: Dr M Balasubramanian

Year round applications PhD Research Project Self-Funded PhD Students Only

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Mining data from National genomics Research Library to enable new gene discovery

University of Sheffield School of Medicine and Population Health

Whole Genome Sequencing (WGS) is a new genomic testing technology and process which became available through the NHS in April 2022. Read more

Supervisor: Dr M Balasubramanian

Year round applications PhD Research Project Self-Funded PhD Students Only

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How are mass extinctions shaping biodiversity?

University of Sheffield School of Biosciences

Background. Understanding the effects of mass extinctions on life on Earth is of crucial importance in the context of the current biodiversity crisis. Read more

Supervisors: Dr T Guillerme, Dr G Thomas

22 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Characterising vegan cheese: Its microstructure and the influence of ingredients and process

Sheffield Hallam University Materials and Engineering Research Institute

The Industry and Innovation Research Institute (I2Ri) draws on talents, expertise and facilities across Sheffield Hallam University. Read more

Supervisors: Dr C Millman, Dr SC Campbell, Dr RG Gillis

10 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Mathematical and Computational Modelling of Haemodynamics for Cerebral Aneurysm Progression

Sheffield Hallam University Materials and Engineering Research Institute

The Industry and Innovation Research Institute (I2Ri) draws on talents, expertise and facilities across Sheffield Hallam University. Read more

Supervisors: Dr JS Spendlove, Prof AS Shenfield, Dr XX Xu, Prof I Halliday

10 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Blue Spaces in Urban Places: Lipidomics Underpinning Community Empowerment

Sheffield Hallam University Biomolecular Sciences Research Centre

The Industry and Innovation Research Institute (I2Ri) draws on talents, expertise and facilities across Sheffield Hallam University. Read more

Supervisors: Dr R Schwartz-Narbonne, Dr ML Lacey, Dr R Sharpe

10 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Diabetes and Breast Cancer from the perspective of oestrogen receptor expression

Sheffield Hallam University Biomolecular Sciences Research Centre

The Industry and Innovation Research Institute (I2Ri) draws on talents, expertise and facilities across Sheffield Hallam University. Read more

Supervisors: Dr SA Ahmed, Dr NP Peake, Dr DK Kelly

10 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Unlocking Precision Medicine: Advanced Survival Analysis Tools for Cancer Biomarker Validation

Sheffield Hallam University Computing and Informatics

The Industry and Innovation Research Institute (I2Ri) draws on talents, expertise and facilities across Sheffield Hallam University. Read more

Supervisors: Dr LQ Quayle, Dr KH Harris, Dr NC Cross

10 May 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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What do effect sizes mean in real terms? Benchmarking effect sizes in behavioural research

University of Sheffield Department of Psychology

A fully-funded studentship is available to work alongside the team working on the BR-UK project (https://www.linkedin.com/company/behavioural-research-uk/) at the University of Sheffield. Read more

Supervisors: Dr H Baird, Prof T Webb

24 April 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Using genome sequencing to find the cause of undiagnosed rare conditions affecting bowel, heart, lung or brain in adults

University of Sheffield School of Medicine and Population Health

In the UK, a rare condition is one that affects fewer than 1/2000 people. Around 70% of rare conditions have a genetic cause (ie are caused by a change… Read more

Supervisor: Dr A McNeill

Year round applications PhD Research Project Self-Funded PhD Students Only

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Role of primary cilia in skeletal muscle stem cells and muscle regeneration

University of Sheffield School of Biosciences

Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more

Supervisor: Dr A G Borycki

Year round applications PhD Research Project Self-Funded PhD Students Only

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Control of skeletal muscle regeneration and aging by cell signalling

University of Sheffield School of Biosciences

The ability of skeletal muscles to regenerate in response to injury, exercise, growth or disease depends on a population of adult skeletal muscle stem cells. Read more

Supervisor: Dr A G Borycki

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genomic and Proteomics-Based Characterisation of Microalgal Cell Factories

University of Sheffield Department of Chemical & Biological Engineering

Microalgae have generated increasing interest as microbial cell factories to produce proteins, pigments, therapeutics, and nutraceuticals. Read more

Supervisors: Dr J Pandhal, Prof MJ Dickman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Glycosylation in Microalgal Host Cells

University of Sheffield Department of Chemical & Biological Engineering

Microalgae have generated increasing interest as microbial cell factories to produce therapeutics proteins. This is because they can grow on very cheap media and their GRAS (generally regarded as safe) status means they are a fantastic option for the production of therapeutics that can be administered orally. Read more

Supervisors: Dr J Pandhal, Dr C Evans

Year round applications PhD Research Project Self-Funded PhD Students Only

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The identification of allosteric inhibitors of high value therapeutic targets

University of Sheffield School of Biosciences

This study will develop a novel approach to identify allosteric inhibitor sites on a wide variety of high-value therapeutic targets, including protein kinases, protein phosphatases and small G-proteins. Read more

Supervisor: Prof J P Waltho

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development of a Long Acting Parathyroid Hormone Fusion for the Treatment of Hypoparathyroidism

University of Sheffield School of Medicine and Population Health

Background. Parathyroid hormone (PTH) is an 84 aa peptide produced by the parathyroid glands and is responsible for calcium homeostasis. Read more

Supervisors: Dr I Wilkinson, Prof J Newell-Price

Year round applications PhD Research Project Self-Funded PhD Students Only

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Finding the cause of familial facial (Bell’s) palsy

University of Sheffield School of Medicine and Population Health

The facial (VII) cranial nerve controls the muscles of facial expression, supplies taste sensation to parts of the tongue and controls a small muscle connected to the ear drum. Bell’s palsy is the clinical condition in which there is impaired function of the facial nerve, associated with facial muscle weakness. Read more

Supervisor: Dr A McNeill

Year round applications PhD Research Project Self-Funded PhD Students Only

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Exploring Uncharted Territories: Investigating the Impact of Follicular Fluid Extracellular Vesicles on Spermatozoa Function

University of Sheffield School of Medicine and Population Health

The intricate dynamics underlying successful mammalian reproduction continue to captivate scientific inquiry. However, the mechanisms governing the interaction between spermatozoa and the female reproductive tract remain elusive. Read more

Supervisor: Prof A Fazeli

Year round applications PhD Research Project Self-Funded PhD Students Only

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Deconvoluting the spatial multi-omic landscape of high-grade glioma to target post-surgical residual disease

University of Sheffield School of Medicine and Population Health

Background. High-grade gliomas are the most common cancers arising within the brain and contribute to ~190,000 brain tumour related deaths/year globally. Read more

Supervisors: Dr S Collis, Dr O Rominiyi, Dr M Dunning

Year round applications PhD Research Project Self-Funded PhD Students Only

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Effect of androgens on preantral follicle development

University of Sheffield School of Medicine and Population Health

Polycystic ovary syndrome (PCOS) is a condition that affects >5% of women of reproductive age and is the most common cause of menstrual dysfunction and is associated with metabolic abnormalities and increased risk to long-term health. Read more

Supervisors: Dr M Fenwick, Dr N Krone

Year round applications PhD Research Project Self-Funded PhD Students Only

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Antisense technologies as potential treatments for Cushing’s disease

University of Sheffield School of Medicine and Population Health

Cushing’s disease is a devastating condition caused by a pituitary corticotroph tumour that over-expresses the proopiomelanocortin gene (POMC) and secretes high levels of ACTH. Read more

Supervisor: Dr E H Kemp

Year round applications PhD Research Project Self-Funded PhD Students Only

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PhD in land-based CO2 removal strategies for climate change mitigation

University of Sheffield School of Biosciences

In a world facing the urgent challenge of climate change, it's clear that we need to take action. This PhD project aims to investigate land-based strategies for removing carbon dioxide (CO2) from the atmosphere. Read more

Supervisor: Dr M Val Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the mechanisms underlying cognitive training effects

University of Sheffield Department of Psychology

Can the repetitive practice of cognitive tasks – as in ’brain training’ programs – effectively enhance cognitive abilities such as reasoning? After more than 20 years of intensive research efforts, this question is still highly controversial, with prior studies and meta-analyses yielding inconsistent results. Read more

Supervisor: Dr C Von Bastian

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 67 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Sheffield

Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Sheffield

We have 67 Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships in Sheffield

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