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We have 56 Biological Sciences PhD Projects, Programmes & Scholarships in Loughborough

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Biological Sciences PhD Projects, Programmes & Scholarships in Loughborough

We have 56 Biological Sciences PhD Projects, Programmes & Scholarships in Loughborough

Loughborough University

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Sarcopenia as a biomarker for people with multiple long-term conditions: an epidemiological perspective

University of Leicester Department of Population Health Sciences
Background . The term ‘multiple long-term conditions’ (MLTCs) refers to the co-existence of two or more chronic conditions (physical or mental) in a person [Navickas et al. Read more
 Supervisor: Dr T Wilkinson
 9 June 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

University of Leicester Department of Genetics and Genome Biology
General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more
 Supervisors: Dr B Warren, Dr E Rosato, Dr R Feuda
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Transgenerational epigenetic consequences of pollution exposure.

University of Leicester Department of Genetics and Genome Biology
Project background. Environmental insults such as pollution can cause transgenerational negative health outcomes in both wild animal populations and humans. Read more
 Supervisor: Dr H Marshall
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding control of genome folding by cohesin

University of Leicester Molecular and Cell Biology
Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more
 Supervisors: Prof D Panne, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Revealing Reactivity in Cancer-Associated Heme Proteins: Novel Time-Resolved Structural Approaches

University of Leicester Molecular and Cell Biology
Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme involved in the degradation of tryptophan to kynurenine. Cancer cells upregulate IDO1 to escape normal immune responses and, in many cases, a high expression of IDO1 is connected to poor prognosis. Read more
 Supervisors: Dr HK Kwon, Dr P A Ash
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Evaluating the impact of genotoxic aldehyde stress in premature ageing

University of Leicester Department of Chemistry
Aldehydes are highly reactive chemicals that are common pollutants and human metabolites. However, the vast majority of aldehydes’ biological functions are unknown. Read more
 Supervisors: Dr R Hopkinson, Dr K Tanaka
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry
Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more
 Supervisors: Dr PA Ash, Dr H Kwon
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Natural products in bacterial physiology and chemical interaction

University of Leicester Department of Genetics and Genome Biology
Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more
 Supervisors: Dr C Jenul, Prof D Jones
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Visual and oculomotor limitations on time pressured text comprehension: Implications for decision-making

University of Leicester School of Psychology and Vision Sciences
Background: . The proposed project brings together two very different areas of research. First, the visual and oculomotor (eye movement control) mechanisms involved in reading. Read more
 Supervisors: Dr SW White, Dr E Krockow
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Understanding the role of pigmentation in retinal and vision development

University of Leicester School of Psychology and Vision Sciences
Establishing structure-function correlations in vision development  . The aim of this project is to develop methods to study the relationship between pigmentation and vision development in humans and zebrafish.  . Read more
 Supervisors: Dr M Thomas, Dr W Norton, Dr J McDearmid
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology
Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more
 Supervisors: Dr MT Tellier, Dr Y Markaki
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Obtaining insights into how a signalling hub protein Ras activates multiple effectors

University of Leicester Molecular and Cell Biology
The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. They are highly conserved from yeast to humans, highlighting their fundamental biological roles. Read more
 Supervisors: Dr K Tanaka , Dr R Mahen
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Unlocking the Secrets of Genome Regulation through cryo-EM

University of Leicester Molecular and Cell Biology
Are you an ambitious spirit, ready to make breakthrough discoveries at the frontier of epigenetics? Dive deep into the fascinating world of eukaryotic genomes with us! . Read more
 Supervisors: Dr T Schalch, Dr AC Chaplin
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Using measures of eye movements and EEG to understand effects of cognitive ageing on reading

University of Leicester School of Psychology and Vision Sciences
Healthy ageing is associated with reductions in visual and cognitive abilities that are required for many activities of daily life (e.g., reading, navigation, object-finding). Read more
 Supervisors: Prof K Paterson, Dr A Pagán
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular level understanding of Mycobacterium tuberculosis

University of Leicester Department of Respiratory Sciences
Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more
 Supervisors: Dr H O'Hare, Dr N Garton
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Failures to detect language errors during older age: Evidence of cognitive decline?

University of Leicester School of Psychology and Vision Sciences
Healthy ageing is associated with well-recognised cognitive decline across multiple domains from age 50 onwards (e.g., working memory, processing speed). Read more
 Supervisors: Dr V McGowan, Dr S Gunn
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetics of early human development: From molecular mechanisms to regenerative medicine

University of Leicester Molecular and Cell Biology
Ever wondered how nature maintains balance of gene expression between sex chromosomes? Well, the 46th chromosome of XX females, the second X, has to be switched off. Read more
 Supervisors: Dr Y Markaki, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetic ageing and calorie restriction in an insect model system

University of Leicester Department of Genetics and Genome Biology
This project will help establish an insect model for epigenetic ageing, by analysing the effects of calorie restriction on chronological and epigenetic aging in an important insect model, Nasonia vitripennis, extending our discovery of an epigenetic clock in Nasonia. . Read more
 Supervisors: Prof E Mallon, Dr K Chen
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Understanding centrosome function in the human airway

University of Leicester Molecular and Cell Biology
Breathing sustains our life and is also important for our quality of life. Inside the lung, billions of hair-like structures called cilia beat a million times a day to promote a process called mucociliary clearance. Read more
 Supervisors: Dr R Mahen, Prof EH Hollox
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Investigating the role of SUMOylation in meiotic recombination and chromosome segregation in Arabidopsis

University of Leicester Department of Genetics and Genome Biology
  Research Group: Midlands Integrative Biosciences Training Partnership (MIBTP)
Post-translational modifications of proteins such as phosphorylation, methylation and acetylation have been extensively studied in eukaryotes and now the Small Ubiquitin modifier (SUMO) is gaining attention for its importance in fundamental biological roles. Read more
 Supervisors: Dr J Higgins, Dr D Guttery
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Unlocking the genetic potential of barley by modulating recombination

University of Leicester Department of Genetics and Genome Biology
Barley is a major worldwide crop used for malting and animal feed. However, breeding new varieties is constrained by the frequency of genetic crossovers (1-3 crossovers per chromosome pair) and their distribution (biased towards the chromosome ends) that underpin crop improvement1,2. Read more
 Supervisors: Dr J Higgins, Dr D Guttery
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Enhancing meiotic recombination in wheat by modulating RECQ helicases

University of Leicester Department of Genetics and Genome Biology
Wheat accounts for 20% of the calories and protein consumed by humans and is the largest crop in the UK, but yields have plateaued and are susceptible to decline due to extreme weather conditions. Read more
 Supervisors: Dr J Higgins, Dr D Guttery
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Exploring the role of tryptophan metabolism in schizophrenia pathogenesis

University of Leicester Department of Genetics and Genome Biology
L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more
 Supervisor: Prof F Giorgini
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Understanding the roles of triacylglycerol in modulating mycobacterial growth and biophysical properties

University of Leicester Department of Respiratory Sciences
Mycobacteria contain more lipid than any other bacteria. In addition to a characteristically lipid-rich cell envelope, mycobacteria can accumulate triacylglycerol (TAG) as cytoplasmic lipid bodies (LBs). Read more
 Supervisors: Dr N Garton , Dr G Mukamolova
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

University of Leicester Molecular and Cell Biology
What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more
 Supervisors: Dr JF Fox, Dr JH Hodgkinson
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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The Evolution of Vision in Mosquitoes

University of Leicester Department of Genetics and Genome Biology
Background . Due to their capacity to transmit viruses such as Zika and parasites like Plasmodium (the causative agent of malaria), mosquitos are regarded by the World Health Organization as one of the most lethal organisms on our planet (WHO | Global vector control response 2017–2030, 2020). Read more
 Supervisors: Dr R Feuda, Dr E Rosato, Dr B Warren
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

University of Leicester Department of Chemistry
Background. The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more
 Supervisors: Dr RD Doveston, Prof S Macip
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular characterization of Sam68-driven cytoskeletal reorganization

University of Leicester Molecular and Cell Biology
The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more
 Supervisors: Dr C Dominguez, Prof A Fry
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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An assessment of the effects of healthy ageing and transcranial Direct Current Stimulation (tDCS) on human foraging cognition

University of Leicester School of Psychology and Vision Sciences
Identifying cognitive markers of human heathy ageing is of extreme importance considering that global population over age 65 is expected to increase by 120% by 2050. Read more
 Supervisors: Dr C De Lillo, Prof E B. Mukaetova-Ladinska
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Identifying the neurogenetic network underlying visually-driven sleep

University of Leicester Department of Genetics and Genome Biology
General background. Sleep is a behavioural quiescence widely observed in the animal kingdom. During sleep, an animal’s motor activity, as well as their responsiveness to environmental stimuli, are largely reduced. Read more
 Supervisors: Dr K Chen, Dr R Feuda
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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