University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

We have 66 University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more

Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn

1 May 2024 PhD Research Project Self-Funded PhD Students Only

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Protecting cells from mechanical stress: A novel role of cell-surface receptor LRP1 in extracellular matrix- nuclei communication.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Cellular adaptation to mechanical strain (mechano-adaptation) is increasingly understood to be conferred by Lamin intermediate filament proteins located within the nuclear lamina. Read more

Supervisor: Dr K Yamamoto

Year round applications PhD Research Project Self-Funded PhD Students Only

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Translating protection of cell-surface receptor LRP1 into potential disease-modifying therapies for osteoarthritis.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Osteoarthritis (OA) causes pain and disability and is the most prevalent age-related joint disorder worldwide but there are no disease-modifying drugs available. Read more

Supervisors: Dr K Yamamoto, Prof G Bou-Gharios

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying age-related extracellular microenvironment in dental tissues

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Periodontal disease is the sixth most globally prevalent age-related disease and a leading cause of tooth loss, significantly impacting quality of life and healthy ageing. Read more

Supervisors: Dr K Yamamoto, Prof FJ Jarad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Preclinical testing of collagen synthesis inhibitors for fibrotic disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Elucidation of a new pathological mechanism for brittle bone disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more

Supervisors: Dr EG Laird, Dr N Longridge, Prof FJ Jarad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences

Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more

Supervisor: Prof LG Yu

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the regulation of neutrophil gene expression by intracellular signalling and small non-coding RNAs

University of Liverpool Institute of Life Course and Medical Sciences

Immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) affect millions of people worldwide and cause debilitating and disabling musculoskeletal disease. Read more

Supervisors: Dr HL Wright, Prof MJ Peffers

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

University of Liverpool Institute of Life Course and Medical Sciences

Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more

Supervisor: Dr VPV Pekovic-Vaughan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the role of neutrophil-mediated tissue damage in a model of lupus nephritis

University of Liverpool Institute of Life Course and Medical Sciences

Systemic lupus erythematosus (SLE) is a rare autoimmune disease that affects around 5 million people worldwide. It disproportionately affects women and is incurable. Read more

Supervisors: Dr HL Wright, Dr D Wilkinson, Dr D Turner

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences

The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more

Supervisor: Dr B Poulet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Morphology, motion, and mechanics of vertebral joints in fish

University of Liverpool Institute of Life Course and Medical Sciences

We depend on healthy joints to stay active, independent and productive. Disorders of the joints of our spine (intervertebral joints) are particularly disruptive, with back pain and disorders impacting millions of people. Read more

Supervisors: Dr A Camp, Dr A Sharp

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the role of Aquaporins in age related diseases

University of Liverpool Institute of Life Course and Medical Sciences

Physical frailty, with its associated immobility and disability, is a major factor limiting independence among older people. A key contributor to frailty is a decline in muscle mass and strength (sarcopenia) and the burden of sarcopenia is substantial, with a cost to the NHS of ~£2.5bn/pa. Read more

Supervisor: Dr C Staunton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype

University of Liverpool Institute of Life Course and Medical Sciences

Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more

Supervisors: Dr R Oldershaw, Dr A Chadwick, Dr M Phelan, Dr BN Norman

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 66 University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

We have 66 University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

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