University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

We have 66 University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

Micro-PIV Investigation of Seabed Reactions to Hydrodynamic Conditions and Energy Changes

University of Liverpool School of Engineering

The EPSRC Centre for Doctoral Training in Net Zero Maritime Energy solutions (N0MES) has a 4-year funded PhD place available for an exceptional researcher. Read more

Supervisors: Prof MMN Mousavi Nezhad, Prof JB Bridgeman

20 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Repeat Physical Traumas an initiator for motor neuron disease (MND): an insight from professional rugby

University of Liverpool Institute of Life Course and Medical Sciences

Motor Neuron Disease (MND) is a devastating condition affecting neuronal cells responsible for voluntary muscle movement. The risk of developing MND is 1 in 300, predominantly in individuals over 50. Read more

Supervisors: Dr C Staunton, Prof A McArdle

20 June 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Engineering polysaccharide sulfotransferases

University of Liverpool Institute of Systems, Molecular and Integrative Biology

The ENZACT Prosperity Partnership is led by UCL and brings together five Universities and two major MNCs. The Liverpool component of ENZACT is focussed on enzymatic sulfation. Read more

Supervisors: Prof D G Fernig, Dr E A Yates, Dr IB Barsukov

14 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Digging into anthropogenic vibrations: investigating the impacts of noise on the physiology and behaviour of benthic and infaunal invertebrates

University of Liverpool Faculty of Science and Engineering

The EPSRC Centre for Doctoral Training in Net Zero Maritime Energy solutions (N0MES) has a 4-year funded PhD place available for an exceptional researcher. Read more

Supervisors: Dr J Thomson, Dr L Roberts

20 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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SEVERITY GRADING AND BIOMARKERS FOR RETINAL VASCULITIS

University of Liverpool Department of Eye and Vision Science

Retinal vasculitis is an important component of inflammatory eye disease or uveitis, as well as a serious adverse effect of new intravitreal treatments. Read more

Supervisor: Dr N Beare

Year round applications PhD Research Project Self-Funded PhD Students Only

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The Role of Nutrition and Exercise in Physical and Cognitive Function (such as sarcopenia and frailty), utilizing clinical, metabolomic, proteomic, and gut microbiota data

University of Liverpool Institute of Life Course and Medical Sciences

Physical frailty is a result of hallmarks of aging, where gut microbiome (GM) dysbiosis and dietary pattern play a significant role. Read more

Supervisor: Dr M Isanejad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Probing Death Decisions from Morphogen Gradient Fields

University of Liverpool Department of Molecular and Clinical Cancer Medicine

Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more

Supervisor: Dr MM Merino

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using single cell transcriptomic and blood proteomic data to understand how pancreatic cancer causes diabetes and to find ways to detect the cancer earlier

University of Liverpool Department of Molecular and Clinical Cancer Medicine

Pancreatic cancer is the deadliest of the common cancers. Five-year survival remains low at 12%. Sadly for 80% of patients, by the time their cancer is diagnosed it has spread to distant organs making them ineligible for potentially curative surgery. Read more

Supervisor: Prof E Costello

23 May 2024 PhD Research Project Self-Funded PhD Students Only

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Investigating local invasion in primary and secondary brain tumours

University of Liverpool Department of Molecular and Clinical Cancer Medicine

Brain tumours are highly invasive and carry a poor prognosis. Secondary brain tumours or brain metastases (BM) are the most common tumours found in the brain affecting up to one third of patients with solid organ cancer. Read more

Supervisor: Dr RZ Zakaria

2 December 2024 PhD Research Project Self-Funded PhD Students Only

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Study of early pathological changes in calcified cartilage in osteoarthritis and alkaptonuria

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

We are seeking a motivated individual to work on this exciting project investigating the role that the calcified cartilage has in rare and common joint osteoarthritis, using novel approaches such as gene silencing and establishment of a 3D chondrocyte cell culture model. Read more

Supervisor: Dr JH Hughes

10 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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The evolution of large brains and complex cognition across animal taxa

University of Liverpool Institute of Systems, Molecular and Integrative Biology

The evolution of advanced cognitive abilities in animals has been heavily studied in some vertebrates, notably mammals and birds. Read more

Supervisor: Dr CM Mitchell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development of novel therapies for Hirschsprung’s Disease

University of Liverpool Faculty of Health and Life Science

As a PhD student, you'll be part of a groundbreaking project aiming to revolutionise the treatment landscape for Hirschsprung's Disease (HSCR). Read more

Supervisors: Miss RH Harwood, Dr B Wilm, Miss SA Almond

26 April 2024 PhD Research Project Funded PhD Project (European/UK Students Only)

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Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

University of Liverpool Department of Pharmacology and Therapeutics

Atrial fibrillation (AF) is a common arrhythmia with symptoms like irregular heart rate, palpitations, shortness of breath, tiredness, and dizziness. Read more

Supervisor: Dr RB Burton

1 July 2024 PhD Research Project Self-Funded PhD Students Only

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Understanding immune recognition in oral premalignant disorders (OPMDs)

University of Liverpool Department of Cellular and Molecular Physiology

Oral potentially malignant disorders (OPMD) are associated with an increased risk of transformation to oral squamous cell carcinoma (OSCC). Read more

Supervisors: Prof K Hunter, Prof NS Savelyeva, Prof C Ottensmeier, Prof RS Shaw

26 April 2024 PhD Research Project Funded PhD Project (European/UK Students Only)

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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology

This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more

Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere

Year round applications PhD Research Project Self-Funded PhD Students Only

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Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more

Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn

1 May 2024 PhD Research Project Self-Funded PhD Students Only

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Protecting cells from mechanical stress: A novel role of cell-surface receptor LRP1 in extracellular matrix- nuclei communication.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Cellular adaptation to mechanical strain (mechano-adaptation) is increasingly understood to be conferred by Lamin intermediate filament proteins located within the nuclear lamina. Read more

Supervisor: Dr K Yamamoto

Year round applications PhD Research Project Self-Funded PhD Students Only

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Translating protection of cell-surface receptor LRP1 into potential disease-modifying therapies for osteoarthritis.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Osteoarthritis (OA) causes pain and disability and is the most prevalent age-related joint disorder worldwide but there are no disease-modifying drugs available. Read more

Supervisors: Dr K Yamamoto, Prof G Bou-Gharios

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying age-related extracellular microenvironment in dental tissues

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Periodontal disease is the sixth most globally prevalent age-related disease and a leading cause of tooth loss, significantly impacting quality of life and healthy ageing. Read more

Supervisors: Dr K Yamamoto, Prof FJ Jarad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Preclinical testing of collagen synthesis inhibitors for fibrotic disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Elucidation of a new pathological mechanism for brittle bone disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more

Supervisors: Dr EG Laird, Dr N Longridge, Prof FJ Jarad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences

Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more

Supervisor: Prof LG Yu

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the regulation of neutrophil gene expression by intracellular signalling and small non-coding RNAs

University of Liverpool Institute of Life Course and Medical Sciences

Immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) affect millions of people worldwide and cause debilitating and disabling musculoskeletal disease. Read more

Supervisors: Dr HL Wright, Prof MJ Peffers

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

University of Liverpool Institute of Life Course and Medical Sciences

Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more

Supervisor: Dr VPV Pekovic-Vaughan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the role of neutrophil-mediated tissue damage in a model of lupus nephritis

University of Liverpool Institute of Life Course and Medical Sciences

Systemic lupus erythematosus (SLE) is a rare autoimmune disease that affects around 5 million people worldwide. It disproportionately affects women and is incurable. Read more

Supervisors: Dr HL Wright, Dr D Wilkinson, Dr D Turner

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences

The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more

Supervisor: Dr B Poulet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Morphology, motion, and mechanics of vertebral joints in fish

University of Liverpool Institute of Life Course and Medical Sciences

We depend on healthy joints to stay active, independent and productive. Disorders of the joints of our spine (intervertebral joints) are particularly disruptive, with back pain and disorders impacting millions of people. Read more

Supervisors: Dr A Camp, Dr A Sharp

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the role of Aquaporins in age related diseases

University of Liverpool Institute of Life Course and Medical Sciences

Physical frailty, with its associated immobility and disability, is a major factor limiting independence among older people. A key contributor to frailty is a decline in muscle mass and strength (sarcopenia) and the burden of sarcopenia is substantial, with a cost to the NHS of ~£2.5bn/pa. Read more

Supervisor: Dr C Staunton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype

University of Liverpool Institute of Life Course and Medical Sciences

Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more

Supervisors: Dr R Oldershaw, Dr A Chadwick, Dr M Phelan, Dr BN Norman

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 66 University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

We have 66 University of Liverpool Biological Sciences PhD Research Projects PhD Projects, Programmes & Scholarships

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