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We have 26 Biological Sciences (mutagenesis) PhD Projects, Programmes & Scholarships

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Biological Sciences (mutagenesis) PhD Projects, Programmes & Scholarships

We have 26 Biological Sciences (mutagenesis) PhD Projects, Programmes & Scholarships

Understanding Spinal Cord Regeneration: The role of dynamic gene expression

Spinal cord injury(SCI) paralysis is a devastating disease that affects at least 2500 people per year in the UK. It carries substantial individual and societal costs with most SCI sufferers experiencing chronic pain. Read more

Revealing Reactivity in Cancer-Associated Heme Proteins: Novel Time-Resolved Structural Approaches

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme involved in the degradation of tryptophan to kynurenine. Cancer cells upregulate IDO1 to escape normal immune responses and, in many cases, a high expression of IDO1 is connected to poor prognosis. Read more

Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more
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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

Graduate Teaching Assistantship. This is a Graduate Training Assistantship (GTA), which means that you will be required to do some teaching, particularly lab demonstrating, as part of your training. Read more

Unravelling the role of genotoxic E. coli in colorectal cancer (SCHULLERS_U24BIGC)

Primary supervisor - Dr Stephanie Schüller. Secondary supervisor - Prof Nathalie Juge. Colorectal cancer (CRC) is the third most common and second most fatal cancer globally. Read more

Elucidation of a new pathological mechanism for brittle bone disease

The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more

Targeting Ras palmitoylation for the treatment of cancer

Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more

Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies

Nuclear factor-kappa B (NF-kB) is a family of transcription factors that play a crucial role in regulating various cellular processes; primarily related to immune responses, inflammation, and cell survival. Read more

Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics

Plastics are a broad range of solid polymeric materials that have found widespread application globally. However, there has been a steady accumulation of discarded plastics and there is now growing awareness that they present a significant hazard to the natural environment and human health. Read more

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