Biological Sciences (t cells) PhD Projects, Programmes & Scholarships

We have 64 Biological Sciences (t cells) PhD Projects, Programmes & Scholarships

Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

University of Leeds Faculty of Medicine and Health

The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more

Supervisors: Dr M Lorger, Dr R Salmond

Year round applications PhD Research Project Self-Funded PhD Students Only

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T Cell Responses in Acute Myeloid Leukaemia

Cancer Research UK Manchester Institute Central

This 4-year PhD studentship will be based at the Cancer Research UK Manchester Institute, New Paterson Building, Withington, Manchester, UK. Read more

Supervisor: Dr M Williams

17 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Self-funded PhD- Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding it in vitro

University of Bristol School of Cellular and Molecular Medicine

Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more

Supervisor: Prof C Wuelfing

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health

T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more

Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban

Year round applications PhD Research Project Self-Funded PhD Students Only

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Mapping CD4+ T cell fate decisions and functional coordination within tissues during infection

The University of Manchester Faculty of Biology, Medicine and Health

CD4+ T cells are essential components of the immune system, orchestrating protection against infection. Read more

Supervisors: Dr K Couper, Prof DD Dyer

Year round applications PhD Research Project Self-Funded PhD Students Only

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Self-funded MSc R- Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding suppression in vitro

University of Bristol School of Cellular and Molecular Medicine

Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more

Supervisor: Prof C Wuelfing

Year round applications PhD Research Project Self-Funded PhD Students Only

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Relationship between IFNγ-dependent tumour escape and immunotherapy

University of Oxford Kennedy Institute of Rheumatology

Tumours actively escape the immune system by inducing an immunosuppressive state whereby intra-tumoural CD8 T-cells are “exhausted”, lacking effector functions. Read more

Supervisors: Dr A Gérard, Dr C Leung

3 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype

University of Liverpool Institute of Life Course and Medical Sciences

Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more

Supervisors: Dr R Oldershaw, Dr A Chadwick, Dr M Phelan, Dr BN Norman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identification and characterization of disease-specific subsets of antigen-presenting cells (APC) in inflammatory arthritis

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cross-talks of immune checkpoint pathways determine the abilities of human malignant tumours to suppress cytotoxic attacks and escape immune surveillance

University of Greenwich School of Pharmacy (Medway Campus)

Overview. Immune checkpoint pathways determine the abilities of human malignant tumours to escape cytotoxic immune attack and thus progress the disease. Read more

Supervisor: Dr V Sumbayev

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cross-talks of immune checkpoint pathways determine the abilities of human malignant tumours to suppress cytotoxic attacks and escape immune surveillance

University of Kent Medway School of Pharmacy

Overview. Immune checkpoint pathways determine the abilities of human malignant tumours to escape cytotoxic immune attack and thus progress the disease. Read more

Supervisor: Dr V Sumbayev

Year round applications PhD Research Project Self-Funded PhD Students Only

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Developing an ADAR-mediated RNA editing therapy for treatment of Duchenne Muscular Dystrophy

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder affecting 1:5000 boys at birth (1). DMD is caused by mutations in Dystrophin gene, with around 10% of the cases caused by nonsense mutations (2,3). Read more

Supervisors: Dr HZ Zhou, Dr J Meng, Prof F Muntoni

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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MScR - Preserving t-tubule function in adult cardiac myocytes in short-term culture

University of Bristol School of Physiology, Pharmacology & Neuroscience

Invaginations of the sarcolemma of adult cardiac myocytes known as transverse (or t-) tubules account for up to 65% of the total sarcolemma surface and play a key role in excitation-contraction (EC) coupling and cell signalling (Hong & Shaw, 2017). Read more

Supervisors: Prof A James, Dr S Harmer

Year round applications PhD Research Project Self-Funded PhD Students Only

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