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We have 58 Other PhD Projects, Programmes & Scholarships in Leicester

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Other PhD Projects, Programmes & Scholarships in Leicester

We have 58 Other PhD Projects, Programmes & Scholarships in Leicester

Loughborough University

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Targeting senescence to ameliorate ageing and treat cancer and other age-related diseases

University of Leicester Molecular and Cell Biology
Ageing is a biological process that affects all humans. Despite the scientific advances of the past decades, the mechanisms that lead to ageing are not fully understood. Read more
 Supervisor: Prof S Macip
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Epigenetics of early human development: From molecular mechanisms to regenerative medicine

University of Leicester Molecular and Cell Biology
Ever wondered how nature maintains balance of gene expression between sex chromosomes? Well, the 46th chromosome of XX females, the second X, has to be switched off. Read more
 Supervisors: Dr Y Markaki, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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An assessment of the effects of healthy ageing and transcranial Direct Current Stimulation (tDCS) on human foraging cognition

University of Leicester School of Psychology and Vision Sciences
Identifying cognitive markers of human heathy ageing is of extreme importance considering that global population over age 65 is expected to increase by 120% by 2050. Read more
 Supervisors: Dr C De Lillo, Prof E B. Mukaetova-Ladinska
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Sarcopenia as a biomarker for people with multiple long-term conditions: an epidemiological perspective

University of Leicester Department of Population Health Sciences
Background . The term ‘multiple long-term conditions’ (MLTCs) refers to the co-existence of two or more chronic conditions (physical or mental) in a person [Navickas et al. Read more
 Supervisor: Dr T Wilkinson
 9 June 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Understanding control of genome folding by cohesin

University of Leicester Molecular and Cell Biology
Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more
 Supervisors: Prof D Panne, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry
Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more
 Supervisors: Dr PA Ash, Dr H Kwon
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Natural products in bacterial physiology and chemical interaction

University of Leicester Department of Genetics and Genome Biology
Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more
 Supervisors: Dr C Jenul, Prof D Jones
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology
Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more
 Supervisors: Dr MT Tellier, Dr Y Markaki
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Using measures of eye movements and EEG to understand effects of cognitive ageing on reading

University of Leicester School of Psychology and Vision Sciences
Healthy ageing is associated with reductions in visual and cognitive abilities that are required for many activities of daily life (e.g., reading, navigation, object-finding). Read more
 Supervisors: Prof K Paterson, Dr A Pagán
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Failures to detect language errors during older age: Evidence of cognitive decline?

University of Leicester School of Psychology and Vision Sciences
Healthy ageing is associated with well-recognised cognitive decline across multiple domains from age 50 onwards (e.g., working memory, processing speed). Read more
 Supervisors: Dr V McGowan, Dr S Gunn
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetic ageing and calorie restriction in an insect model system

University of Leicester Department of Genetics and Genome Biology
This project will help establish an insect model for epigenetic ageing, by analysing the effects of calorie restriction on chronological and epigenetic aging in an important insect model, Nasonia vitripennis, extending our discovery of an epigenetic clock in Nasonia. . Read more
 Supervisors: Prof E Mallon, Dr K Chen
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Dissecting the interplay of extracellular vesicle signalling and tryptophan metabolism in schizophrenia pathogenesis

University of Leicester Department of Genetics and Genome Biology
L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more
 Supervisor: Prof F Giorgini
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Understanding the roles of triacylglycerol in modulating mycobacterial growth and biophysical properties

University of Leicester Department of Respiratory Sciences
Mycobacteria contain more lipid than any other bacteria. In addition to a characteristically lipid-rich cell envelope, mycobacteria can accumulate triacylglycerol (TAG) as cytoplasmic lipid bodies (LBs). Read more
 Supervisors: Dr N Garton , Dr G Mukamolova
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

University of Leicester Molecular and Cell Biology
What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more
 Supervisors: Dr JF Fox, Dr JH Hodgkinson
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular characterization of Sam68-driven cytoskeletal reorganization

University of Leicester Molecular and Cell Biology
The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more
 Supervisors: Dr C Dominguez, Prof A Fry
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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