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We have 58 University of Bristol, Bristol Medical School PhD Projects, Programmes & Scholarships

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University of Bristol, Bristol Medical School PhD Projects, Programmes & Scholarships

We have 58 University of Bristol, Bristol Medical School PhD Projects, Programmes & Scholarships

University of Bristol

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Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

University of Bristol Bristol Medical School
The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more
 Supervisor: Prof T Gaunt
 20 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Integrative genomics prioritisation of drug targets

University of Bristol Bristol Medical School
The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more
 Supervisor: Prof T Gaunt
 20 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Synthesizing evidence on different outcome scales: development of mapping methods for continuous outcome data in meta-analysis

University of Bristol Bristol Medical School
Evidence synthesis techniques are used to combine data from multiple medical trials to compare different treatment options for the same condition. Read more
 Supervisor: Prof J Higgins
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring the value of using large third-party artificial intelligence models in epidemiology, with examples using Twitter/X data

University of Bristol Bristol Medical School
Large language models (LLMs) are an artificial intelligence approach that typically have a very large number of parameters (e.g. millions or billions) and have been trained on extremely large datasets. Read more
 Supervisor: Dr L Millard
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Quantifying prognosis in the current era of antiretroviral therapy among persons with HIV in Europe and North America across different HIV acquisition route groups

University of Bristol Bristol Medical School
In Europe and North America, prognosis for persons with HIV (PWHIV) has improved since the introduction of combined antiretroviral in 1996[1]. Read more
 Supervisor: Dr SI Ingle
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating causal mechanisms between parental social disadvantage and risk of ADHD to the offspring

University of Bristol Bristol Medical School
Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental condition, characterised by persistent difficulties in the areas of attention span/impulse control. Read more
 Supervisor: Dr E Stergiakouli
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring Parkinson’s disease subtypes using data driven approaches applied to prospective cohorts

University of Bristol Bristol Medical School
Parkinson’s disease is a progressive neurodegenerative disorder characterised by a wide range of motor and non-motor features, for which there is no known cause. Read more
 Supervisor: Dr M Lawton
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The management of young people's mental health in primary care

University of Bristol Bristol Medical School
Before the COVID-19 pandemic, new prescriptions for medication used to treat anxiety and depression were increasing in young people [1, 2]. Read more
 Supervisor: Dr C Archer
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding the role of adiponectin in kidney disease development at a population level

University of Bristol Bristol Medical School
Reduced circulating adiponectin levels are associated with poor outcome in patients with diabetic kidney disease (DKD) (1). Adiponectin has been shown to be protective against the development of DKD in Type 2 diabetic models (2, 3, 4). Read more
 Supervisor: Dr R Foster
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the interactions of incretin hormone mimetics with hypothalamo-neurohypophysial system arginine vasopressin and oxytocin release

University of Bristol Bristol Medical School
Our research focus over decades has been the osmoregulatory function of a special collection of neurones in a part of the brain called the hypothalamus. Read more
 Supervisor: Prof D Murphy
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School
Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more
 Supervisor: Dr J Min
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

University of Bristol Bristol Medical School
Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more
 Supervisor: Prof S Satchell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

University of Bristol Bristol Medical School
Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more
 Supervisor: Dr P Maghsoudlou
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Automating Literature Mining and Triangulation with Large Language Models and Knowledge Graphs

University of Bristol Bristol Medical School
Around 1.7 million new articles were published in PubMed in 2022, with a further 47,000 pre-prints posted on bioRxiv and medRxiv in the same period. Read more
 Supervisors: Dr Y Liu, Prof T Gaunt
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the causal relationship between atopic dermatitis and cardiovascular disease in multiple ancestry groups

University of Bristol Bristol Medical School
Atopic dermatitis (AD) or eczema affects 20% of children and 10% of adults, where the prevalence is reported to be higher among individuals of Asian and African ancestry. Read more
 Supervisor: Dr A Budu-Aggrey
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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