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We have 57 University of Bristol, Bristol Medical School PhD Research Projects PhD Projects, Programmes & Scholarships

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University of Bristol, Bristol Medical School PhD Research Projects PhD Projects, Programmes & Scholarships

We have 57 University of Bristol, Bristol Medical School PhD Research Projects PhD Projects, Programmes & Scholarships

University of Bristol

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Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

University of Bristol Bristol Medical School
The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more
 Supervisor: Prof T Gaunt
 20 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Integrative genomics prioritisation of drug targets

University of Bristol Bristol Medical School
The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more
 Supervisor: Prof T Gaunt
 20 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School
Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more
 Supervisor: Dr J Min
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

University of Bristol Bristol Medical School
Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more
 Supervisor: Prof S Satchell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

University of Bristol Bristol Medical School
Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more
 Supervisor: Dr P Maghsoudlou
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Automating Literature Mining and Triangulation with Large Language Models and Knowledge Graphs

University of Bristol Bristol Medical School
Around 1.7 million new articles were published in PubMed in 2022, with a further 47,000 pre-prints posted on bioRxiv and medRxiv in the same period. Read more
 Supervisors: Dr Y Liu, Prof T Gaunt
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the causal relationship between atopic dermatitis and cardiovascular disease in multiple ancestry groups

University of Bristol Bristol Medical School
Atopic dermatitis (AD) or eczema affects 20% of children and 10% of adults, where the prevalence is reported to be higher among individuals of Asian and African ancestry. Read more
 Supervisor: Dr A Budu-Aggrey
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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What outcomes are important to patients with osteoarthritis? Development of a core outcome set

University of Bristol Bristol Medical School
Osteoarthritis is the most common musculoskeletal condition worldwide and is the leading cause of disability in the UK. In our recent study to identify research priorities in osteoarthritis, the highest priority question to patients was “What outcomes are important to patients?”[1]. Read more
 Supervisor: Prof M Whitehouse
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Epilepsy and the ageing brain

University of Bristol Bristol Medical School
Our ability to remember ‘where I put my car keys today’ instead of ‘where I put them yesterday’ depends on a computational process called pattern separation. Read more
 Supervisor: Dr D Atan
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Developing tailored solutions to under-recruiting randomised controlled trials: a mixed-methods investigation

University of Bristol Bristol Medical School
Randomised controlled trials (RCTs) drive evidence-based medicine, but they can be resource-intensive and challenging to conduct. Read more
 Supervisor: Dr L Rooshenas
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Metabolomic characterisation of adiposity across the life course

University of Bristol Bristol Medical School
There is evidence that adiposity, measured by body mass index (BMI), causally influences a range of health outcomes, but little understanding of the mechanisms driving BMI effects. Read more
 Supervisor: Dr L Corbin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Updating the background characteristics and risk factors associated with Sudden Infant Death Syndrome (SIDS) to inform risk-reduction messages and help target vulnerable families

University of Bristol Bristol Medical School
Our team has been instrumental in reducing the number of cot deaths (SIDS or Sudden Infant Death Syndrome) in England & Wales by 90% over the last three decades.[1] The remaining 2-300 unexpected infant deaths per year show a marked inequality, largely coming from socio-economically deprived communities. Read more
 Supervisor: Prof P Blair
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring the value of using large third-party artificial intelligence models in epidemiology, with examples using Twitter/X data

University of Bristol Bristol Medical School
Large language models (LLMs) are an artificial intelligence approach that typically have a very large number of parameters (e.g. millions or billions) and have been trained on extremely large datasets. Read more
 Supervisor: Dr L Millard
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Quantifying prognosis in the current era of antiretroviral therapy among persons with HIV in Europe and North America across different HIV acquisition route groups

University of Bristol Bristol Medical School
In Europe and North America, prognosis for persons with HIV (PWHIV) has improved since the introduction of combined antiretroviral in 1996[1]. Read more
 Supervisor: Dr SI Ingle
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating causal mechanisms between parental social disadvantage and risk of ADHD to the offspring

University of Bristol Bristol Medical School
Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental condition, characterised by persistent difficulties in the areas of attention span/impulse control. Read more
 Supervisor: Dr E Stergiakouli
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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