We have 88 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

The impressive range of anatomical variations observed in animals along their body axis is the result of distinct control mechanisms governing gene expression. Read more

Supervisors: Prof N Bobola, Dr M Birket

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating immune contributions to frontotemporal dementia and motor neuron disease

The University of Manchester Faculty of Biology, Medicine and Health

Frontotemporal dementia (FTD) is the 2nd most common form of dementia affecting younger people, with a typical age of onset in the mid-late 50s. Read more

Supervisors: Dr SR Ryan, Prof D Brough

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Investigating the genetic basis of immunological overlap between inflammatory diseases

The University of Manchester Faculty of Biology, Medicine and Health

Genetic studies have identified numerous variants within the human genome associated with susceptibility to common complex inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis (UC). Read more

Supervisors: Mr P Martin, Prof S Eyre, Prof A Morris

Year round applications PhD Research Project Self-Funded PhD Students Only

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A deep-learning approach to genomic regulation of tissue-specific alternative splicing

The University of Manchester Faculty of Biology, Medicine and Health

Each human gene is a blueprint for multiple distinct RNA transcripts that can be produced in differing quantities based on the localisation of the transcribing… Read more

Supervisors: Dr JE Eales, Prof T Papamarkou

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterisation of how pro-peptide regions of collagen control extracellular matrix homeostasis, in health and musculoskeletal diseases

The University of Manchester Faculty of Biology, Medicine and Health

Collagen-I (‘collagen’ from hereon) is the most abundant protein in the human body (circa 25% of total protein mass), providing structure to organs with very different functions (e.g. Read more

Supervisors: Dr JC Chang, Dr TZ Zacharchenko, Prof C Baldock

Year round applications PhD Research Project Self-Funded PhD Students Only

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Clinical Prediction Modelling under Federated Learning

The University of Manchester Faculty of Biology, Medicine and Health

Clinical prediction models (CPMs) take a set of characteristics about a patient to estimate their risk of an event of interest. Developing CPMs using data that captures observations across multiple clusters (e.g., countries) can increase the robustness and generalisability of CPMs. Read more

Supervisors: Dr G P Martin, Dr M Sperrin, Dr DJ Jenkins

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health

Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more

Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Nitrate supplementation in pregnancy: maternal, fetal and offspring outcomes

The University of Manchester Faculty of Biology, Medicine and Health

Maternal diet has a significant impact on fetal growth and development, as well as pregnancy outcomes and long-term offspring health. Dietary patterns… Read more

Supervisors: Dr E Cottrell, Dr M Dilworth

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding Spinal Cord Regeneration: The role of dynamic gene expression

The University of Manchester Faculty of Biology, Medicine and Health

Spinal cord injury(SCI) paralysis is a devastating disease that affects at least 2500 people per year in the UK. It carries substantial individual and societal costs with most SCI sufferers experiencing chronic pain. Read more

Supervisors: Dr X Soto Rodriguez, Dr K Dorey, Dr Cerys Manning

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health

Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more

Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

The University of Manchester Faculty of Biology, Medicine and Health

The chronic inflammatory skin disease, eczema, now affects approximately 15% of the paediatric population of the Western world and is growing in prevalence. Read more

Supervisors: Prof CN O'neill, Prof A McBain

Year round applications PhD Research Project Self-Funded PhD Students Only

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Imagery in Action in Parkinson’s disease

The University of Manchester Faculty of Biology, Medicine and Health

Parkinson’s disease is a neurodegenerative condition affecting around 1 in 500 people, with significant impact on movements, which are typically slower and smaller. Read more

Supervisors: Dr E Poliakoff, Dr E Gowen

Year round applications PhD Research Project Self-Funded PhD Students Only

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Communication and co-speech gestures in Parkinson’s disease

The University of Manchester Faculty of Biology, Medicine and Health

Parkinson’s disease is a neurodegenerative condition affecting around 1 in 500 people, with significant impact on movements and quality of life. Read more

Supervisors: Dr E Poliakoff, Dr P Conroy

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 88 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

We have 88 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

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