We have 91 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

There are almost a million people living with dementia in the UK. Most of these cases comprise Alzheimer’s Disease (AD), vascular dementia (VaD) or, as is increasingly recognised, a mixed picture phenotype with evidence of the two conditions co-existent in the same patient. Read more

Supervisors: Dr H Pritchard, Dr A Greenstein, Dr I Schiessl, Prof S Allan

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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(BRC) Nailfold capillary imaging in the idiopathic inflammatory myopathies (Non-Clinical)

The University of Manchester Faculty of Biology, Medicine and Health

The idiopathic inflammatory myopathies (IIMs) are rare conditions characterised by distinct clinical subtypes and varied multisystem involvement. Read more

Supervisors: Dr A Murray, Dr H Chinoy, Dr J Lamb

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health

We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more

Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) A prototype smart disposable device for ophthalmic point-of-care

The University of Manchester Faculty of Biology, Medicine and Health

This project seeks to design and develop a small device which will fit comfortably behind the lower eyelid in order to soak up a small volume of tears such that the biomarkers contained in tears – including some of the thousands or proteins in the human tear film – can be easily removed and analysed. Read more

Supervisors: Prof P Morgan, Prof J Gough

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Determination of the role of viruses in the microbiome of biofilms formed in the ear of patients with otitis media

The University of Manchester Faculty of Biology, Medicine and Health

Otitis media (OM) is a very common infection of the middle ear characterised by redness, swelling and build-up of fluid behind the eardrum. Read more

Supervisors: Prof P Vallely, Prof P Klapper, Prof S Lovell, Mrs JN Nichani

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) The emerging fungal order Mucorales: species-specific pathogenic strategies and new diagnostics

The University of Manchester Faculty of Biology, Medicine and Health

Mucormycoses are emerging lethal fungal infections, with striking mortality rates of 50-90% depending on the clinical presentation, infection site and underlying host immune status. Read more

Supervisors: Dr M Bertuzzi, Dr N.V.R Van Rhijn

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Investigating the mechanisms contributing to impaired regulatory function of B cells in autoimmunity

The University of Manchester Faculty of Biology, Medicine and Health

The implementation of biological therapies has significantly advanced the management of autoimmune diseases (AIDs). However, the failure to achieve clinical remission in ‘non-responders’ remains a significant and unmet challenge. Read more

Supervisors: Dr MM Mennon, Prof MH Buch

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Understanding Disease Management and Outcomes for Myositis Patients: An International Real-World Study Utilising Multiple Data Sources to Investigate Treatment Patterns, Health-Related Quality of Life, Clinical Outcomes, and Burden of Illness for Patients With Rare Autoimmune Disease

The University of Manchester Faculty of Biology, Medicine and Health

Myositis is a group of rare conditions which present with physical symptoms that can significantly impact a patient’s life. Many patients are permanently disabled due to irreversible muscle damage. Read more

Supervisors: Dr H Chinoy, Dr AO Oldroyd

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

The University of Manchester Faculty of Biology, Medicine and Health

Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more

Supervisors: Prof D Brough, Dr K Couper

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) An Integrative Structural Biology Platform for Drug Discovery

The University of Manchester Faculty of Biology, Medicine and Health

Solute carriers (SLCs) are the second largest class of membrane-embedded proteins with over 400 members organised into 66 families. Read more

Supervisors: Dr A Politis, Dr CP Pliotas

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Designing Peptide hydrogels as vehicles for targeted and localised in-vivo therapeutics delivery

The University of Manchester Faculty of Biology, Medicine and Health

One of the key engineering challenges in the life-science and biomedical sectors is the design and manufacturing of bespoke hydrogels for 3D cell culture, tissue engineering and cell/drug delivery. Read more

Supervisors: Prof A Saiani, Dr K Finegan

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Mapping CD4+ T cell fate decisions and functional coordination within tissues during infection

The University of Manchester Faculty of Biology, Medicine and Health

CD4+ T cells are essential components of the immune system, orchestrating protection against infection. Read more

Supervisors: Dr K Couper, Prof DD Dyer

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health

T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more

Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban

Year round applications PhD Research Project Self-Funded PhD Students Only

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VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data

The University of Manchester Faculty of Biology, Medicine and Health

Rare diseases affect. This proposal builds on substantial efforts of a Human Genome Organization committee which has proposed a unified professional-standard for representing genomic data which, when finalised, will be adopted world-wide. Read more

Supervisors: Dr S Pettifer, Dr PF Freeman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

The University of Manchester Faculty of Biology, Medicine and Health

RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more

Supervisors: Dr RB Bryce, Dr S Butterworth, Dr T Jowitt, Dr A Ucar

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The University of Manchester Faculty of Biology, Medicine and Health

The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more

Supervisors: Dr M Lagator, Prof M Rattray

Year round applications PhD Research Project Self-Funded PhD Students Only

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Delineating the IRF6 regulatory network driving periderm formation and function

The University of Manchester Faculty of Biology, Medicine and Health

During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more

Supervisors: Prof M Dixon, Dr J Dixon

Year round applications PhD Research Project Self-Funded PhD Students Only

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Eco-evolutionary optimization of synthetic phage therapy

The University of Manchester Faculty of Biology, Medicine and Health

Background. Bacteriophages are viruses that infect bacterial cells, use their cellular machinery to assemble new phage virions, and then kill the cell via lysis to release the virions. Read more

Supervisors: Prof M Brockhurst, Prof P Cai, Dr CI Igler

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Ocular staining with lissamine green

The University of Manchester Faculty of Biology, Medicine and Health

This project will explore issues related to ocular staining with lissamine green. Read more

Supervisors: Dr P Morgan, Dr C Maldonado-Codina

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating inequalities in the safety of artificial intelligence triage in general practice

The University of Manchester Faculty of Biology, Medicine and Health

Background. GP practices in England provide over 30 million appointments per month. Some are for urgent medical conditions that require urgent treatment where delays in care can lead to patient harm. Read more

Supervisors: Dr B Brown, Dr S Cheraghi-Sohi, Prof E Kontopantelis

26 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Decluttering primary care in England to improve patient safety

The University of Manchester Faculty of Biology, Medicine and Health

Reducing the provision of low-value interventions that expose patients to unnecessary risk of harm, both directly, and indirectly, is key to promoting patient safety and reducing healthcare costs. Read more

Supervisors: Prof E Kontopantelis, Dr M Anderson, Dr RP Parisi, Dr K.H Howells, Prof C Armitage

26 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Repurposing Treg cells for TIL therapy

The University of Manchester Faculty of Biology, Medicine and Health

Tumour-infiltrating lymphocytes (TIL) therapy is an experimental therapy which uses ex-vivo expanded TIL as a source of living drug to treat cancer. Read more

Supervisors: Dr A Hurlstone, Prof M Travis, Prof R Edmondson, Prof F Thistlethwaite

19 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Eco-evolutionary dynamics of environmental microbiomes

The University of Manchester Faculty of Biology, Medicine and Health

Include details on the project, outlining the objectives, methods and potential outcomes. Include details of training/techniques to be provided. Read more

Supervisors: Prof M Brockhurst, Dr S Nixon, Dr K Coyte

15 June 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

The University of Manchester Faculty of Biology, Medicine and Health

Genomic variation that impacts splicing is well established as a cause of genomic disorders, but is almost exclusively limited to protein-coding exons and introns intersecting protein-coding exons. Read more

Supervisors: Dr J Ellingford, Prof R O'Keefe

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Assessing the contribution of the human microbiome to paediatric cancer and predisposition and chromosomal instability syndromes

The University of Manchester Faculty of Biology, Medicine and Health

A self-funded PhD studentship is available in the laboratories of Andrew McBain, Stefan Meyer and Chris Knight. The project aims to study the microbiome in paediatric cancer predisposition and chromosomal instability syndromes (CIS). Read more

Supervisors: Prof A McBain, Dr S Meyer, Dr C Knight

Year round applications PhD Research Project Self-Funded PhD Students Only

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Peptide-mediated nanocarrier drug delivery for enhanced brain targeting and treatment of inflammation

The University of Manchester Faculty of Biology, Medicine and Health

This project involves the study of nanoparticles and drug delivery to the brain. The student would be required to make and characterise novel nanoparticles from special lipid molecules of various compositions more suitable for blood-brain barrier (BBB) targeting. Read more

Supervisors: Dr HS Shokr, Dr CT Tapeinos, Dr H Aojula

Year round applications PhD Research Project Self-Funded PhD Students Only

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Optimising the measurement of working memory for assessment of speech-in-noise perception

The University of Manchester Faculty of Biology, Medicine and Health

The ability to hear and understand speech in a noisy background is vitally important to good communication, and ultimately a good quality of life. Read more

Supervisors: Dr A Heinrich, Dr R Millman, Dr S Couth

Year round applications PhD Research Project Self-Funded PhD Students Only

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Collective problem-solving and rationality in early childhood

The University of Manchester Faculty of Biology, Medicine and Health

Reasoning has traditionally been viewed as an individual skill. However, recent accounts emphasize its social dimension (Mercier & Sperber, 2011) suggesting that collectives can make inferences to maximize the outcomes for both the individual and the collective (Tomasello, 2019). Read more

Supervisors: Dr B.K Koymen, Dr B.LP Lopez-Perez, Dr K Jensen, Dr B.K Kandemirci

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis affecting children and young people with an age of disease onset less than 16 years of age. Read more

Supervisors: Dr J Bowes, Dr J Humphreys

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 91 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

We have 91 The University of Manchester, Faculty of Biology, Medicine and Health PhD Research Projects PhD Projects, Programmes & Scholarships

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