We have 912 career PhD Projects, Programmes & Scholarships

Tousled-like kinase 2 (TLK2) was recently identified as a novel genetic locus for a neurodevelopmental disorder. Patients predominantly possess de novo mutations in TLK2, leading to a reduction in its expression or kinase activity. Read more

Supervisors: Dr G Evans, Dr I Hahn

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding Hormone Regulation in Skin Cancer Development and Progression

University of York York Biomedical Research Institute

Skin cancers, including melanoma and non-melanoma skin cancers, pose a significant global health burden. While the role of hormones in skin cancer development and progression remains an underexplored area, recent research has suggested potential links between hormonal regulation and skin cancer outcomes. Read more

Supervisors: Dr M Yamada, Prof T Prow

Year round applications PhD Research Project Self-Funded PhD Students Only

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Metal-based Antimicrobials: Tackling Resistance with Catalytic Redox Stressors

University of York York Biomedical Research Institute

Background. New antibiotics are urgently needed to combat the widespread rise in resistance. However, only very few of the drug candidates in clinical development represent new structural classes. Read more

Supervisors: Prof A-K Duhme-Klair, Prof G Thomas, Prof G Barlow

Year round applications PhD Research Project Self-Funded PhD Students Only

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Role of the endosomal pathway in regulating sleep and circadian rhythms

University of York York Biomedical Research Institute

Ageing and many neurodegenerative disorders are characterised by a progressive loss of neurons in particular brain regions leading to behavioural changes including cognitive decline, sleep disruption and circadian dysregulation. Read more

Supervisors: Dr S Chawla, Dr S Sweeney

Year round applications PhD Research Project Self-Funded PhD Students Only

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Ejecting infection: Understanding how epithelial tissues rid themselves of viral infections by apical extrusion

University of York York Biomedical Research Institute

Background. The epithelial tissues of our bodies use physical barriers and innate defences to fight viral infection. Read more

Supervisor: Dr S Baker

Year round applications PhD Research Project Self-Funded PhD Students Only

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Discovery and functional investigation of the shared molecular mechanisms of host immunoregulation by the pathogens that cause malaria and sepsis.

University of York York Biomedical Research Institute

Infectious diseases cause enormous humanitarian and economic burdens worldwide. Designing interventions that prevent, cure, or control many infections is difficult because pathogens have evolved sophisticated ways of subverting host immunity. Read more

Supervisor: Prof GJ Wright

Year round applications PhD Research Project Self-Funded PhD Students Only

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Modulation of host immune response by secreted proteins from parasitic worms

University of York York Biomedical Research Institute

Background. To establish chronic infection, parasitic worms manipulate their mammalian hosts’ immune system. This immune modulation is often mediated by excreted or secreted parasite glycoproteins (ES proteins). Read more

Supervisors: Dr CR Crosnier, Dr J Hewitson, Dr A Kay

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the role and regulation of membraneless granules for the development of T. brucei

University of York York Biomedical Research Institute

Adaptation to a change of environment is an essential process for survival, in particular for parasitic organisms exposed to a wide range of hosts. Read more

Supervisors: Dr M Cayla, Dr P B Walrad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Validation of Assistive Product design interventions using multi-sensory modalities measured through biometric measures

Loughborough University School of Design and Creative Arts

The World Health Organization states. "An estimated 1.3 billion people experience significant disability. This represents 16% of the world’s population, or 1 in 6 of us.". Read more

Supervisor: Dr G Torrens

1 May 2024 PhD Research Project Self-Funded PhD Students Only

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Chemical modification of proteins via metal-mediated processes

University of York York Biomedical Research Institute

Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more

Supervisors: Dr C Spicer, Dr M Plevin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding interactions of proteins with polymer-coated nanoparticles

University of York York Biomedical Research Institute

Introduction. Polymer-coated nanoparticles are promising drug delivery vehicles. Multiple functionalities can be embedded into the nanoparticle structure to enable uptake of the drug-like molecules, their targeted delivery and controlled release. Read more

Supervisors: Prof V Chechik, Prof D Ungar

Year round applications PhD Research Project Self-Funded PhD Students Only

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Making sense of antigenic variation in trypanosomes: a nuclear factory with a switching problem

University of York York Biomedical Research Institute

Trypanosomes are master of disguise. African trypanosomes cause huge morbidity and economic burden amongst some of the world’s poorest populations. Read more

Supervisors: Dr J Faria, Dr R McCulloch

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the Role of Subcortical Visual Pathways for 'Blindsight' and Gist Perception in Parkinson's Disease Using Multimodal Neuroimaging and Computational Neuroscience

University of York York Biomedical Research Institute

Parkinson's disease (PD) is primarily known as a movement disorder, but emerging evidence suggests that it might also significantly impact visual processing, specifically 'blindsight' and gist perception (Diederich et al., 2014;Uchiyama st al., 2012). Read more

Supervisors: Assoc Prof K Evans, Prof A Wade

Year round applications PhD Research Project Self-Funded PhD Students Only

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Unravelling mechanisms of cytoskeletal regulation that control neuronal health and disease

University of York York Biomedical Research Institute

Axons are the slender, often meter-long processes of neurons which electrically wire the brain. These delicate structures are up to a meter long and need to be maintained for decades. Read more

Supervisors: Dr I Hahn, Dr S Sweeney, Prof A Wade

Year round applications PhD Research Project Self-Funded PhD Students Only

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Ion channel signalling in cancer cells

University of York York Biomedical Research Institute

Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more

Supervisor: Dr W Brackenbury

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 912 career PhD Projects, Programmes & Scholarships

career PhD Projects, Programmes & Scholarships

We have 912 career PhD Projects, Programmes & Scholarships

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