We have 505 inclusion PhD Projects, Programmes & Scholarships

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Supervisors: Prof R O'Keefe, Prof B Newman

Year round applications PhD Research Project Self-Funded PhD Students Only

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New Methods for modelling cofactor-dependent enzyme structure and function

The University of Manchester Department of Chemistry

Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more

Supervisor: Prof S Hay

27 October 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Inflammatory Arthritis in Childhood: Impact, Outcomes and Safety of Treatment

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile Idiopathic Arthritis is the most common inflammatory arthritis of childhood. Although less common than arthritis in adults, a diagnosis of arthritis in a child can have lasting impacts on that child and their families through their entire lifespan. Read more

Supervisors: Prof K Hyrich, Dr L Kearsley-Fleet

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of Human cytomegalovirus glycoprotein polymorphisms in disease pathogenesis

The University of Manchester Faculty of Biology, Medicine and Health

Human cytomegalovirus (HCMV) produces asymptomatic infection in most immunocompetent individuals but thereafter establishes life-long infection with periodic reactivation and asymptomatic shedding. Read more

Supervisors: Prof P Vallely, Prof P Klapper

Year round applications PhD Research Project Self-Funded PhD Students Only

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Discerning the role of metabolic proteins in nucleus

The University of Manchester Faculty of Biology, Medicine and Health

Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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Evaluating the risk of biguanides and statins on cancer incidence and mortality rates: a mixed methods study combining pharmacoepidemiological and experimental approaches

The University of Manchester Faculty of Biology, Medicine and Health

In the UK, every two minutes someone is diagnosed with cancer and every four minutes someone dies from it– leading to more than 360,000 new cases and 160,000 deaths annually1. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

The University of Manchester Faculty of Biology, Medicine and Health

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more

Supervisors: Dr R Hager, Dr M Harte, Dr J Glazier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

The University of Manchester Faculty of Biology, Medicine and Health

Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more

Supervisors: Dr G. Morris, Dr R Wykes, Prof R Baines

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the protective effects of a commensal bacterial strain in skin barrier function and protection from disease

The University of Manchester Faculty of Biology, Medicine and Health

Maintaining a healthy skin barrier is vital for our health. In response to skin wounding, we have a well-orchestrated immune response that heals the breach. Read more

Supervisors: Prof S Cruickshank, Prof A McBain, Dr R Unwin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development of a decision tool for people offered bone conduction hearing implants

The University of Manchester Faculty of Biology, Medicine and Health

Background. Some people with hearing loss cannot wear conventional hearing aids and a bone conduction hearing implant (BCHI) might be considered. Read more

Supervisors: Dr RP Powell, Dr K Kluk, Dr S Peters, Mr KG Green, Dr PFH Feltham-Hill

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genotypic and phenotypic markers of resistance in Aspergillus fumigatus and their impact on outcomes in chronic pulmonary aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

Chronic pulmonary aspergillosis (CPA) is a progressive infection affecting patients with chronic lung disease. It significantly affects quality of life and mortality. Read more

Supervisors: Dr CK Kosmidis, Dr M Bromley, Dr R Richardson, Dr M Bottery, Prof T Hussell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Drug repurposing for the treatment of aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

The mould Aspergillus fumigatus was classified by the WHO as a critical priority pathogen in 2022. It causes a spectrum of invasive, allergic and chronic disease. Read more

Supervisors: Dr CK Kosmidis, Prof D Ashcroft, Dr M Bottery, Dr M Bromley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identification and characterization of disease-specific subsets of antigen-presenting cells (APC) in inflammatory arthritis

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Dysfunctional antifungal potency of the respiratory mucosa in COPD

The University of Manchester Faculty of Biology, Medicine and Health

Inhalation of Aspergillus fumigatus spores cause >3,000,000 chronic and >200,000 invasive diseases annually worldwide. Invasive aspergillosis carries a 50% mortality rate overall, but mortality rate approaches 100% if diagnosis is delayed or missed and it is >75% in certain cohorts of patients, such as COPD sufferers. Read more

Supervisors: Dr M Bertuzzi, Dr J.H Herbert, Dr S Gago

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development and validation of a radiosensitivity gene expression signature in prostate cancer

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is diagnosed in 1.4 million men globally each year and causes 375,000 deaths, making PCa the second most common cancer and fifth most common cause of death from cancer in men[1]. Read more

Supervisors: Prof A Choudhury, Dr MR Reardon, Dr TS Smith

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 505 inclusion PhD Projects, Programmes & Scholarships

inclusion PhD Projects, Programmes & Scholarships

We have 505 inclusion PhD Projects, Programmes & Scholarships

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