protein expression PhD Projects, Programmes & Scholarships

We have 139 protein expression PhD Projects, Programmes & Scholarships

Understanding the uncertainty in the decomposition of cancer gene or protein expression data

University of St Andrews School of Mathematics and Statistics

Research Group: Division of Statistics

Many tools exist that will take the expression profile of a tumour sample and decompose that signal into components arising from different tissue types (e.g. Read more

Supervisors: Dr M Papathomas, Prof A Lynch

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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PI3K-Akt expression in dysplastic oral lesions and implications for recurrence and malignant transformation

University of Dundee Dental School

There are around 12,400 new head and neck cancer cases in the UK every year, that's 34 every day (2016-2018) with 4,143 deaths each year. Read more

Supervisors: Prof M Macluskey, Dr I Ellis, Dr M Islam, Dr S. J. Jones

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Treatment and biomarker development for inherited manganese transporter defects using cell models of SLC30A10 deficiency

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Manganese is essential to human health and development. However, excess manganese is neurotoxic causing manganism, a neurodegenerative disorder characterised by dystonia-parkinsonism. Read more

Supervisors: Dr K Tuschl, Dr P Mills, Dr WH Heywood

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Targeting Ras palmitoylation for the treatment of cancer

University of Dundee School of Medicine

Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more

Supervisor: Dr N Fraser

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Membrane protein-metabolite interactions important in mitochondrial energy metabolism for burning fat as heat (CRICHTON_U24DTP)

University of East Anglia Norwich Medical School

Primary supervisor - Dr Paul Crichton . Secondary supervisor - Prof. Tom Clarke (UEA) . Mitochondria in our cells harness energy through the breakdown of nutrients to produce ATP through oxidative phosphorylation. Read more

Supervisor: Dr P Crichton

9 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

University of Leicester Molecular and Cell Biology

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

Supervisors: Dr JF Fox, Dr JH Hodgkinson

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy

University of Nottingham School of Medicine

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more

Supervisors: Prof K Gaston, Dr S Jayaraman

Year round applications PhD Research Project Self-Funded PhD Students Only

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The Survivin Interactome in Health and Disease

University of Nottingham School of Life Sciences

Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more

Supervisor: Dr S Wheatley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders

University of Leeds Faculty of Biological Sciences

The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisor: Prof I Wood

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterisation of how pro-peptide regions of collagen control extracellular matrix homeostasis, in health and musculoskeletal diseases

The University of Manchester Faculty of Biology, Medicine and Health

Collagen-I (‘collagen’ from hereon) is the most abundant protein in the human body (circa 25% of total protein mass), providing structure to organs with very different functions (e.g. Read more

Supervisors: Dr JC Chang, Dr TZ Zacharchenko, Prof C Baldock

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the regulation of neutrophil gene expression by intracellular signalling and small non-coding RNAs

University of Liverpool Institute of Life Course and Medical Sciences

Immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) affect millions of people worldwide and cause debilitating and disabling musculoskeletal disease. Read more

Supervisors: Dr HL Wright, Prof MJ Peffers

Year round applications PhD Research Project Self-Funded PhD Students Only

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Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease

University of Birmingham School of Biomedical Sciences

Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more

Supervisors: Dr I Pienaar, Prof J.F. Collingwood

Year round applications PhD Research Project Self-Funded PhD Students Only

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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

University of Bradford Faculty of Life Sciences

Research Group: Institute of Cancer Therapeutics

Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

Supervisors: Dr S Shnyder, Dr S Kantamneni

Year round applications PhD Research Project Self-Funded PhD Students Only

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Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

University of Bristol Bristol Medical School

Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more

Supervisor: Dr P Maghsoudlou

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chemical modification of proteins via metal-mediated processes

University of York York Biomedical Research Institute

Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more

Supervisors: Dr C Spicer, Dr M Plevin

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 139 protein expression PhD Projects, Programmes & Scholarships

protein expression PhD Projects, Programmes & Scholarships

We have 139 protein expression PhD Projects, Programmes & Scholarships

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