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We have 87 protein structure PhD Projects, Programmes & Scholarships

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protein structure PhD Projects, Programmes & Scholarships

We have 87 protein structure PhD Projects, Programmes & Scholarships

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Structure and activity of VDR and RARγ, their targeting compounds and complexes

The doctoral candidate (DC) will perform structural biology type research focused on obtaining, purifying and structural analysis of binding domains of VDR and RARγ full receptors, their targeting compounds and complexes formed by these receptors. Read more

Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more

Development of LA1011 for high affinity binding to Hsp90 for use towards healthy ageing in patients showing Alzheimer’s symptoms

  Research Group: Biochemistry
With 50 million global cases of Alzheimer’s disease (AD) and care costs of 1 trillion UK pounds (expected to triple by 2050), there is a pressing need to slow disease progression, sustain productive lives and reduce costs. Read more

Investigating the role of P2X7 receptor intracellular domains in cell signalling

Project description. P2X7 receptors are ion channels that are found on the surface of immune cells, where they respond to the binding of extracellular ATP, a damage signal released by dying cells in infection and injury. Read more

Exosome biogenesis and organelle trafficking in neurodegeneration.

Scientific summary. Intracellular transport pathways are fundamental for cell structure and function. Due to their longevity, complex morphology (long axonal and dendritic extensions) and requirement to maintain synaptic transmission, neurons are heavily dependent upon intracellular transport. Read more

Revealing Reactivity in Cancer-Associated Heme Proteins: Novel Time-Resolved Structural Approaches

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme involved in the degradation of tryptophan to kynurenine. Cancer cells upregulate IDO1 to escape normal immune responses and, in many cases, a high expression of IDO1 is connected to poor prognosis. Read more

Molecular characterization of Sam68-driven cytoskeletal reorganization

The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more

Machine Learning and Molecular Modelling in Mass Spectrometry

This PhD project will harness the power of computational modelling and machine learning (A.I.) to analyse data obtained by mass spectrometry experiments and predict structural characteristics of biomolecules and their interactions. Read more

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