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We have 40 regulation of gene expression PhD Projects, Programmes & Scholarships

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regulation of gene expression PhD Projects, Programmes & Scholarships

We have 40 regulation of gene expression PhD Projects, Programmes & Scholarships

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Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Masaryk University Faculty of Medicine
Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more
 Supervisor: Dr D Blažek
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The University of Manchester Faculty of Biology, Medicine and Health
The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more
 Supervisors: Dr M Lagator, Prof M Rattray
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the regulation of neutrophil gene expression by intracellular signalling and small non-coding RNAs

University of Liverpool Institute of Life Course and Medical Sciences
Immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) affect millions of people worldwide and cause debilitating and disabling musculoskeletal disease. Read more
 Supervisors: Dr HL Wright, Prof MJ Peffers
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

University of Leeds Faculty of Medicine and Health
Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more
 Supervisors: Prof M Wilcox, Dr K Davies, Dr A Buckley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Assessment of phototherapy with model organism Saccharomyces cerevisiae

University of Reading Department of Biomedical Engineering
Project Overview.  . Saccharomyces cerevisiae is extensively used as model organism and is well understood from a sequencing perspective so up-regulation or down-regulation of gene expression is tractable. Read more
 Supervisors: Dr S Hadjiloucas, Dr E Delivopoulos
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring the role of tryptophan metabolism in schizophrenia pathogenesis

University of Leicester Department of Genetics and Genome Biology
L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more
 Supervisor: Prof F Giorgini
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Investigating the role and regulation of membraneless granules for the development of T. brucei

University of York York Biomedical Research Institute
Adaptation to a change of environment is an essential process for survival, in particular for parasitic organisms exposed to a wide range of hosts. Read more
 Supervisors: Dr M Cayla, Dr P B Walrad
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Regulation of gingival mast cells activity by valproic acid-potential to repurpose for treatment of periodontitis?

Queen Mary University of London Institute of Dentistry
Background. Periodontitis or chronic inflammation of the tooth-supporting tissues caused by a dysbiotic biofilm is the main cause of tooth loss in the adult population. Read more
 Supervisor: Dr F Flores-Borja
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self funded MSc by research or PhD in Biology: Membraneless biomelecular condensates, a major regulator of trypanosome parasites differentiation and host adaptation

University of York Department of Biology
Lead supervisor: Dr Mathieu Cayla. Co-Supervisor. Dr Pegine Walrad. The student will be registered with the Department of Biology. Read more
 Supervisor: Dr M Cayla
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: m6A modification of segmentation clock mRNAs and its role in somitogenesis

University of Dundee School of Life Sciences
During early embryogenesis, segments (somites) are formed during a process called somitogenesis. These somites will go on to form the bones and muscles of the skeleton. Read more
 Supervisors: Prof J K Dale, Dr P Murray
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding gene regulation by HDAC1 complexes in development and cancer

University of Leicester Molecular and Cell Biology
Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more
 Supervisor: Prof S Cowley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Genetic interactions and novel genes that regulate lignin biosynthesis and straw quality in barley

University of Dundee School of Life Sciences
Lignin is a major component of plant cell walls, and has a significant influence on the digestibility and uses of plant biomass. The lignin biosynthesis pathway has been one of the most intensively studied. Read more
 Supervisor: Prof C Halpin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype

University of Liverpool Institute of Life Course and Medical Sciences
Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more
 Supervisors: Dr R Oldershaw, Dr A Chadwick, Dr M Phelan, Dr BN Norman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisor: Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

University of Liverpool Institute of Life Course and Medical Sciences
Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more
 Supervisor: Dr VPV Pekovic-Vaughan
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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