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We have 17 cytokine PhD Projects, Programmes & Scholarships

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cytokine PhD Projects, Programmes & Scholarships

We have 17 cytokine PhD Projects, Programmes & Scholarships

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Preclinical testing of collagen synthesis inhibitors for fibrotic disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more
 Supervisor: Dr EG Laird
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Dissecting the interplay of extracellular vesicle signalling and tryptophan metabolism in schizophrenia pathogenesis

University of Leicester Department of Genetics and Genome Biology
L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more
 Supervisor: Prof F Giorgini
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: Unravelling the pre-clinical immunology of the IL-23/1L-17 axis in axial inflammation in psoriatic arthritis towards optimal disease prevention

University of Leeds Faculty of Medicine and Health
Psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are key disorders within the seronegative spondylarthropathy (SpA) that was first described in… Read more
 Supervisors: Prof D McGonagle, Dr H Marzo-Ortego, Dr T Macleod
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

The University of Manchester Faculty of Biology, Medicine and Health
The chronic inflammatory skin disease, eczema, now affects approximately 15% of the paediatric population of the Western world and is growing in prevalence. Read more
 Supervisors: Prof CN O'neill, Prof A McBain
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders

University of Leeds Faculty of Biological Sciences
The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisor: Prof I Wood
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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How does glycolysis influence the oral environment during caries and periodontitis?

University of Sheffield School of Clinical Dentistry
Glycolysis plays a pivotal role during energy metabolism and cellular responses in oral health and pathology. It is a crucial metabolic pathway for energy production, especially in inflammation or infection scenario, that is essential for maintaining tissue integrity and function in the gingiva and dental pulp. Read more
 Supervisors: Dr C M Neves, Prof G Stafford
 31 May 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Immune regulation of lung repair, and long-term consequences of infection

University of Edinburgh School of Biological Sciences
This project is one of 14 four year PhD Studentships funded by Medical Research Scotland (MRS) (https://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and External Partner Organisation (EPO). Read more
 Supervisors: Prof G Perona-Wright, Dr S Jenkins
 14 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Investigating the role of neutrophil-mediated tissue damage in a model of lupus nephritis

University of Liverpool Institute of Life Course and Medical Sciences
Systemic lupus erythematosus (SLE) is a rare autoimmune disease that affects around 5 million people worldwide. It disproportionately affects women and is incurable. Read more
 Supervisors: Dr HL Wright, Dr D Wilkinson, Dr D Turner
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Helminth products as macrophage “trainers”: a novel tool to induce anti-inflammatory trained immunity

Kingston University Faculty of Health, Science, Social Care and Education
The innate immune system can display characteristics of immunological memory. This phenomenon, termed “trained immunity”, refers to the long-term functional reprogramming of innate immune cells after the encounter with infectious or non-infectious agents that influences their capacity to respond to a secondary stimulus. Read more
 Supervisor: Dr N Garrido Mesa
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

University of Bristol Bristol Medical School
Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more
 Supervisor: Dr P Maghsoudlou
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Diagnostics for FMF patients and carrier survival in pandemics

The University of Manchester Faculty of Biology, Medicine and Health
Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more
 Supervisors: Dr P Arkwright, Dr G Lopez-Castejon, Dr J Cavet
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Molecular characterisation of the factors driving lung fibrosis

University of Dundee School of Life Sciences
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that results in an irreversible decline in lung function.  At present IPF is normally fatal and the median survival is between 2 and 5 years after diagnosis. Read more
 Supervisors: Prof S Arthur, Dr H McSorley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Investigation of accentuated mitochondrial ROS and NLRP3 inflammasome activation in cystic fibrosis and colorectal carcinoma.

University of Leeds Faculty of Medicine and Health
Cystic fibrosis (CF) is associated with an accentuated inflammatory response to bacterial lipopolysaccharides (LPS), increased resting energy expenditure and a higher than expected prevalence of gastrointestinal and other malignancies. Read more
 Supervisors: Prof D Peckham, Prof D Jayne, Dr S Savic, Miss LR Caley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Unlocking immune cells with tick-borne pathogens

University of Bristol Faculty of Health Sciences
In this project we will use tick-borne pathogenic bacteria as a molecular tool-kit for unlocking immune cells. These discoveries will help us combat tick-borne disease and provide a basis for manipulating immune cells, impacting on a wide range of diseases. Read more
 Supervisors: Dr I Cadby, Dr J Mann, Dr E Ballou
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Molecular mechanism of vimentin induced epithelial mesenchymal transition (EMT) and stemness in cancer cells

Queen Mary University of London Institute of Dentistry
Background. Most cancers are epithelial in origin and arise from a single progenitor cell, similar to an embryo, to become a clone of cells. Read more
 Supervisors: Prof A Waseem, Dr H Tummala, Dr F Flores-Borja
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Possible role of mutant vimentin in cancer progression and metastasis

Queen Mary University of London Institute of Dentistry
Background. This project will investigate the role of the cytoskeletal protein vimentin in cancer progression and metastasis using cell and molecular biology approaches. Read more
 Supervisors: Prof A Waseem, Dr F Flores-Borja, Dr H Tummala
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the impact of inflammation on cardiovascular disease

University of Birmingham Institute of Cardiovascular Sciences
We are seeking talented, motivated students with a passion for research in cardiovascular inflammation and immune-mediated chronic inflammatory diseases to join the group of Dr Asif Iqbal (Dr Asif Iqbal - Institute of Cardiovascular Sciences - University of Birmingham). Read more
 Supervisor: Dr A Iqbal
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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