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We have 21 embryo PhD Projects, Programmes & Scholarships

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embryo PhD Projects, Programmes & Scholarships

We have 21 embryo PhD Projects, Programmes & Scholarships

Developmental consequences of heat stress during early mammalian embryogenesis

Epidemiological evidence in humans indicates that acute heat exposure around the time of mating results in pregnancy loss, with potential long-term consequences for offspring health and wellbeing; although these latter adverse effects are poorly understood. Read more

Biophysical explorations of neural crest cell behaviours in development and cancer

Neural crest cells are highly migratory. These cells travel throughout the developing embryo, eventually contributing to most organ systems, including the peripheral nervous system, pigment cells and craniofacial skeleton. Read more

Uncovering the mechanochemical signalling inputs that drive gastruloid axial patterning

How the early mammalian embryo converts a mass of identical cells in an organism with multiple axes of symmetry (anteroposterior, dorsoventral, mediolateral) is a critical question in developmental biology. Read more

MSc by Research: Function of presomitic mesoderm specific phosphorylation of the Notch intracellular domain in somitogenesis

The Notch signalling pathway is one of the key pathways required for the developing embryo. It is especially important for the process of somitogenesis, the formation of body segments that develop into e.g. Read more

Gene regulation in cancer metastasis

A PhD project studying gene regulation in cancer metastasis is available in the laboratory of Dr. Fiona Wardle (https://www.kcl.ac.uk/research/wardle-group) in the Randall Centre for Cell and Molecular Biophysics, King’s College London. Read more

Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more
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