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We have 49 metastasis PhD Projects, Programmes & Scholarships

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metastasis PhD Projects, Programmes & Scholarships

We have 49 metastasis PhD Projects, Programmes & Scholarships

Gene regulation in cancer metastasis

A PhD project studying gene regulation in cancer metastasis is available in the laboratory of Dr. Fiona Wardle (https://www.kcl.ac.uk/research/wardle-group) in the Randall Centre for Cell and Molecular Biophysics, King’s College London. Read more

Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more

Assessing the molecular mechanisms by which Cathepsin V promotes breast cancer growth and metastasis

Targeted therapies such as tamoxifen, fulvestrant and anastrozole have exhibited significant clinical success since being introduced as treatments for Estrogen Receptor positive (ER+) breast cancer patients. Read more

Cell biology and evolution of cancer metastasis

We are interested in the spread of cancer, a process called metastasis. Metastasis is responsible for the majority of cancer deaths and there are currently no effective treatments to stop this process. Read more

The role of vitamin D3 in treating skin cancer and preventing drug resistance

  Research Group: Chemistry and Biosciences
During the last decade numerous studies have alluded to vitamin D. 3. playing a role in the prevention of cancer. Recent clinical trials looking at the potential role of vitamin D. Read more

Investigating how tumour associated macrophages affect cancer metastasis and response to therapies

Solid tumours are generally highly infiltrated by macrophages. Macrophages are heterogeneous and different populations with different and sometimes even opposite functions co-exist in tumours affecting cancer progression. Read more

Driving phenotypic plasticity and metastasis in small cell lung cancer

Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more

Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells. Read more

Genomic actions of RAR and VDR ligands

The Doctoral Candidate (DC) will determine whether the combination of RARγ antagonist and VDR agonist is suitable as a differentiation therapy against acute myeloid leukaemia (AML). Read more

Structure and activity of VDR and RARγ, their targeting compounds and complexes

The doctoral candidate (DC) will perform structural biology type research focused on obtaining, purifying and structural analysis of binding domains of VDR and RARγ full receptors, their targeting compounds and complexes formed by these receptors. Read more

Sensitizing AML cells to RAR and VDR ligands (vitamin A and D derivatives) to prevent leukaemia relapse

The doctoral candidate (DC) will perform basic research on leukaemia cell biology in vitro and in vivo at the Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel. Read more

Development of a highly innovative label-free & deep-learning based analysis method: Histoplasmonic Tissue Cytometry

The doctoral candidate (DC) will perform applied research in bioinformatics, i.e., the extraction of numerical values from biological samples, by engaging deep learning technologies to microscopic images with the aim to develop a novel solution for future clinical diagnostics of cancer. Read more

Investigating molecular drivers of cell invasion

The Wells laboratory focusses on exploring the molecular mechanisms that underlie cell invasion. We have interests in cancer cell invasion and hemopoietic cell invasion. Read more

Investigating the roles that G protein coupled receptors play in hypertension

G protein-coupled receptors (GPCRs) constitute a very large family of heptahelical, integral membrane proteins that mediate a wide variety of physiological processes ranging from the transmission of light and odorant signals to the mediation of neurotransmission and hormonal actions. Read more

How does myosin 10 contribute to filopodia formation and stability?

How do cells make filopodia? Filopodia are thin protrusions that act as pathfinders in cell migration, helping cells to sense where to go, and pulling cells through the extracellular matrix, especially important in driving cancer cell metastasis. Read more

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