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We have 89 molecular microbiology PhD Projects, Programmes & Scholarships

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molecular microbiology PhD Projects, Programmes & Scholarships

We have 89 molecular microbiology PhD Projects, Programmes & Scholarships

Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more

Targeting the sweet tooth to curb population-wide sugar intake

Excess intake of dietary sugars are a major contributor to obesity, and type 2 diabetes and 82% of people state that taste is the major determinant of what they buy and eat. Read more

Dynamic Imaging for Real-Time Visualization of Bacterial Species Co-Distribution and Biofilm Matrix Components

Dental caries is a severe problem for both health and the economy. This oral disease is multifactorial and biofilm-dependent, caused by changes in the composition and metabolism of complex bacterial communities in oral biofilms. Read more

Chance or Necessity: Elucidating host adaptation in atypical Salmonella

Food security is a key sustainable development goal for the United Nations (UN) and it is estimated that more than two billion people did not have access to safe, nutritious and/or sufficient food in 2019. Read more

Development of Nanomaterials for Targeting the Bacteria–Host Interface in Cystic Fibrosis Airways

The attachment of Pseudomonas aeruginosa (PA) to the airway mucus in the lungs of people with cystic fibrosis (CF) represents an important step in airway colonization and the subsequent development of lung infection. Read more

Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more

Evaluating Bacterial Acid Production and pH Dynamics in a Real-Time In-Vitro Polymicrobial Biofilm Model

Dental caries still remains a severe problem for both health and the economy. This oral disease is multifactorial and biofilm-dependent, caused by changes in the composition and metabolism of complex communities of oral biofilm. Read more

Functional characterization of gonococcal toxin-antitoxin systems

Toxin-antitoxin (TA) systems are commonly found in bacteria and comprise a stable toxin able to stall bacterial replication and an antitoxin that neutralises the activity of the toxin. Read more

Regulation of virulence and biofilm formation by quorum sensing and the "stress alarmone" ppGpp in gram-negative pathogenic bacteria.

We are investigating the complex interplay between cell-cell signalling (quorum sensing), microbial lifestyle (i.e., free-living planktonic cultures vs sessile biofilm communities), growth phase and virulence in gram-negative bacteria. Read more

Where has all of the carbon gone? Understanding the molecular mechanisms of long-term soil carbon capture

Soils, while unglamorous, form the basis of the terrestrial biosphere and are ultimately the source of the majority of the food that we eat, yet fundamental aspects of how soils form and how they store carbon are poorly understood. Read more

Optimizing phage-antibiotic-synergies to kill bacterial pathogens

Phage therapy, the use of viruses that only infect bacterial cells and kill them, is a promising potential solution to the antimicrobial resistance crisis that is threatening modern medicine1. Read more

PhD Project on Defining Links Between Climate Change, Marine Disease and Food Security

This PhD project will apply cutting edge approaches in molecular microbial ecology to deliver. critical new knowledge on the causes of marine pathogen outbreaks that threaten Australia’s. Read more

Linking metabolism and metal resistance in pathogenic bacteria (SULLIVANM_U24AMSSCI)

Primary supervisor - Dr Matthew Sullivan. Group B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Read more

Developing 3D models to understand how interactions between bacterial biofilm and the host environment impact antimicrobial efficacy in a chronic infected wound

2.8 million people in the UK have a chronic wound which persist for months or years, causing pain, isolation, odour, and decreased mobility; patients with chronic wounds regularly report a deterioration in quality of life. Polymicrobial biofilms are present in greater than 70% of chronic wounds, making effective treatment incredibly challenging. Read more

Exploring the molecular mechanisms of skin aging process and understanding the relationship between skin aging and systemic aging

Applicants are invited for fully funded 3 years full time PhD studentships, starting from 1st February 2023, or 1st April 2023, or 1st October 2023 at latest, based in the School of Pharmacy, The University of Nottingham. Read more

Natural products in bacterial physiology and chemical interaction

Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more

Exploring Viral Nucleic Acid Machinery via Cryo Electron Microscopy to Advance Biomedicine

Viruses, these tiny but potent life forms, are all around us, infecting various organisms and directly affecting human health. Although in most cases, viral infection is not life threatening, in the minority of cases it leads to long-term disorders including cancer. Read more

The role of regulatory evolution in phage ecology

The regulation of genes crucially determines the fitness and function of all organisms. This is particularly relevant for bacteriophages, the viruses that infect bacteria, as they rely on a tightly scheduled program for a successful infection. Read more

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