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We have 15 patch clamp PhD Projects, Programmes & Scholarships

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patch clamp PhD Projects, Programmes & Scholarships

We have 15 patch clamp PhD Projects, Programmes & Scholarships

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Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

The University of Manchester Faculty of Biology, Medicine and Health
Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more
 Supervisors: Dr G. Morris, Dr R Wykes, Prof R Baines
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self funded MSc by Research or PhD in Biology: Delineating neuronal structure and function in the autism spectrum disorder neurofibromatosis type 1

University of York Department of Biology
Neurofibromatosis type 1 (NF1) is among the most common monogenetic disorders of humans and patients show a high prevalence of Autism Spectrum Disorders. Read more
 Supervisors: Dr I Hahn, Dr W Brackenbury
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Pharmacology of ion channels in human genetic disorders

University of Leeds Faculty of Biological Sciences
The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisors: Dr J D Lippiat, Dr S Clapcote, Dr K Simmons, Dr S Muench
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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A Patient-derived 3D humanized model of ADCY5-related disease to accelerate therapeutic approaches for patients

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
ADCY5-related disease is a genetic disorder caused by mutations in the ADCY5 gene, which encodes for the isoform 5 of adenylyl cyclase (ADCY5)1. Read more
 Supervisors: Dr S Barral, Dr M Kurian, Dr HZ Zhou
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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MScR - Preserving t-tubule function in adult cardiac myocytes in short-term culture

University of Bristol School of Physiology, Pharmacology & Neuroscience
Invaginations of the sarcolemma of adult cardiac myocytes known as transverse (or t-) tubules account for up to 65% of the total sarcolemma surface and play a key role in excitation-contraction (EC) coupling and cell signalling (Hong & Shaw, 2017). Read more
 Supervisors: Prof A James, Dr S Harmer
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self funded MSc by Research or PhD in Biology: Ion channel signalling in cancer cells

University of York Department of Biology
Lead supervisor: Dr W Brackenbury. The student will be registered with the Department of Biology. Our cells constantly sense and transport ions present in their environment. Read more
 Supervisor: Dr W Brackenbury
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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SLS SF3: PhD in Pharmacological intervention of ion channels for the treatment of cardiac disease

University of Westminster School of Life Sciences
Within our lab we study human ion channels, mainly potassium channels, that contain genetic mutations which lead to disease states. Read more
 Supervisors: Dr KP Cunningham, Dr S Getting, Dr DG Gaze
 17 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Ion channel signalling in cancer cells

University of York York Biomedical Research Institute
Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more
 Supervisor: Dr W Brackenbury
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease

University of Birmingham School of Biomedical Sciences
Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more
 Supervisors: Dr I Pienaar, Prof J.F. Collingwood
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides

University of Nottingham School of Life Sciences
The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more
 Supervisor: Dr I R Mellor
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Dissecting behaviourally relevant feedback microcircuits in the brain

Queen Mary University of London Blizard Institute
Interactions between distinct neural circuits in the brain help in sensory-guided perceptual decisions. We have recently reported that task/context-switching behaviour is dependent upon specific populations of neurons in the frontal cortex which encode and convey rule-related information (Banerjee et al. Read more
 Supervisor: Prof A.B Banerjee
 10 May 2024  PhD Research Project  Funded PhD Project (European/UK Students Only)
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3D printing spinal cords

University of Reading Department of Biomedical Engineering
Project Overview. This project offers an exciting opportunity to use hydrogels and 3D printing to engineer a segment of the spinal cord, which could be further developed into a transplant for patients with spinal cord injury (SCI). Read more
 Supervisor: Dr E Delivopoulos
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Combining laser and ultrasound based molecular delivery strategies for enhanced drug delivery

University of Dundee School of Science and Engineering
Overview. This project addresses the critical area of delivering therapeutics to the skin. If successful, the approach will have direct and positive consequences for the treatment of a range of skin diseases, but may also be viewed as a more generic means of drug delivery for treating a much wider range of disease. Read more
 Supervisors: Dr P Campbell, Dr R Hickerson
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Model-predictive control of brain plasticity for optimal non-invasive brain stimulation

The University of Manchester Faculty of Biology, Medicine and Health
Neuroplasticity is the mechanism that underpins the brain’s ability to learn or recovery from traumatic events, but also its deterioration underlies several Neurodegenerative diseases and mental illnesses. Read more
 Supervisors: Dr N Trujillo-Barreto, Dr C Lea-Carnall
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Deriving functional neurons from hIPSCs

University of Reading Department of Biomedical Engineering
Neuronal networks grown on petri dishes encode information as electrical activity. This activity is dictated by their underlying structural and functional connectivity. Read more
 Supervisors: Dr E Delivopoulos, Dr F Tamagnini
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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