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We have 12 University of Liverpool Other PhD Projects, Programmes & Scholarships

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Medicine

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University of Liverpool

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University of Liverpool Other PhD Projects, Programmes & Scholarships

We have 12 University of Liverpool Other PhD Projects, Programmes & Scholarships

Preclinical testing of collagen synthesis inhibitors for fibrotic disease

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more

Elucidation of a new pathological mechanism for brittle bone disease

The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more

Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition

Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more

The effect of low protein diet on the development of the neuromuscular system

Age-related sarcopenia is characterised by reduction in the number of myofibres and motor neurons and an additional weakening of the remaining fibres, causing reduction in muscle mass and function. Read more

The development and application of metabolomics tools to study human metabolism in health and disease

Metabolites play many important roles in humans including through metabolism to support our growth and health, through incorporation of lipids in cell membranes to influence transport of biochemicals in to and out of cells and to regulate biochemical processes. Read more

Molecular characterisation of a novel transporter for the atypical antipsychotic clozapine

Schizophrenia is a severe psychiatric illness affecting about 24 million people worldwide. Schizophrenia can have a devastating effect on a patient’s life and is associated with increased mortality, with life expectancy reduced on average by 15 years compared to that of the general population. Read more

Mechanisms controlling gene expression in hypoxia and inflammation

Oxygen is one of the most important molecules for life. Every member of the animal kingdom depends on oxygen to help metabolize its food and drive many critical processes in metabolism. Read more
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