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We have 20 Other (unknown) PhD Projects, Programmes & Scholarships

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Other (unknown) PhD Projects, Programmes & Scholarships

We have 20 Other (unknown) PhD Projects, Programmes & Scholarships

The effect of early-life stress on cardiac function in later life

Stressful experiences in early childhood can increase the risk of cardiovascular disease (CVD) in later life. How early-life stress (ELS) influences susceptibility to CVD onset remains largely unknown. Read more

Investigating how dormant senescent cells can drive drug-resistance following chemotherapy

Most anti-cancer chemotherapeutics work by inducing DNA damage and arresting the cell cycle in either G1 or G2 phase. A frequent outcome of this arrest is that cells exit the cell cycle into a state known as senescence. Read more

The BCAT1 CXXC Motif and Oncogenesis in Acute Myeloid Leukaemia

The BCAT1 gene is implicated in the pathogenesis of many cancer types, including acute myeloid leukaemia (AML)1–4. Recently, our group identified a novel antioxidant role for BCAT1 in AML cells5. Read more
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Health inequalities in medication adherence in those with cardiometabolic disease(s)

Background. Medication adherence, defined as the degree to which the person’s behaviour corresponds with the agreed recommendations from a health care provider [1], is often low in those with cardiometabolic conditions, in particular hypertension [2]. Read more

Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more

Structural investigation of oncogenic splicing factors

More than 90% of human genes can and do express multiple proteins. This is achieved by a process called alternative RNA splicing, which is an essential step in gene expression in mammals. Read more

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