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We have 26 Toxicology (development) PhD Projects, Programmes & Scholarships

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Toxicology (development) PhD Projects, Programmes & Scholarships

We have 26 Toxicology (development) PhD Projects, Programmes & Scholarships

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The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

The University of Manchester Faculty of Biology, Medicine and Health
A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more
 Supervisors: Dr R Hager, Dr M Harte, Dr J Glazier
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of Naked Mole Rat Colonic Crypt Models to Use in the Search for Bowel Disease Preventatives

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Diseases affecting the bowel such as colorectal cancer (CRC) and the inflammatory bowel diseases (IBD) ulcerative colitis and Crohn’s disease are major global healthcare challenges in the 21st century. Read more
 Supervisors: Dr S Shnyder, Prof S El-Khamisy
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Engineering functional human tissue: Development of a 3D cerebral microvascular model with blood brain barrier function.

University of Strathclyde Department of Biomedical Engineering
There is mounting research interest in tissue engineered models of human blood brain barrier (BBB) due to the prevalence of central nervous system (CNS) disease in modern societies. Read more
 Supervisors: Dr J Wu, Prof W Shu
 15 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Development of a personalized therapy for pulmonary arterial hypertension (PAH)

University of Bradford Faculty of Life Sciences
  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more
 Supervisor: Dr T Nasim
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Targeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Prostate cancer is one of the leading causes of male cancer deaths. It arises when individual cells escape their normal growth control mechanisms and proliferate in an uncontrolled fashion. Read more
 Supervisors: Dr J Muller, Prof R Falconer
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences
Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more
 Supervisor: Prof LG Yu
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Polysialyltransferases as a target in metastatic cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Hepatic Models to personalise cancer chemotherapy

University of Liverpool Department of Pharmacology and Therapeutics
The most commonly used chemotherapy regimens for colorectal cancer with liver metastases are oxaliplatin combined with 5-FU and leucovorin, i.e. Read more
 Supervisors: Prof C Goldring, Dr A Chadwick, Prof IC Copple, Dr S Pushpakom
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Personalising cancer treatment with tumour evolution modelling using AI-based genomics biomarkers and PK/PD

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Tumour heterogeneity is a major problem limiting the efficacy of targeted oncological therapies. Most advanced tumours eventually become resistant to the treatments, ultimately making the patient succumb to metastatic disease. Read more
 Supervisor: Dr T You
 1 August 2024  PhD Research Project  Self-Funded PhD Students Only
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Interaction between innate immune activation and endothelial cells, linked to adverse cardiovascular events

University of Liverpool Institute of Systems, Molecular and Integrative Biology
The complement system is a key component of the immune response. Maintaining a balance between activation and inhibition of the complement system is key to preserving tissue homeostasis and enabling immune surveillance. Read more
 Supervisors: Dr N Liptrott, Dr R Rainbow, Prof C Dart
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Novel strategies for the diagnosis and treatment of snakebites

University of Reading School of Pharmacy
Snakebite envenomation (SBE), a high priority neglected tropical disease affects several million people worldwide resulting in as many as 150,000 deaths and around 500,000 permanent disabilities every year. Read more
 Supervisor: Prof SV Vaiyapuri
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer

University of Reading School of Pharmacy
Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells. Read more
 Supervisor: Prof D Widera
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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A 3D-Printed Blood-Brain-Barrier-on-a-Chip for Agrochemical Permeability Studies – CASE Studentship

University of Liverpool Department of Physics
The blood-brain barrier (BBB) tightly regulates the flow of material between the bloodstream and the brain. One of the big problems faced by a range of sectors, from pharmaceuticals to agrochemicals, is understanding how compounds interact with and cross this barrier. Read more
 Supervisors: Dr J Forth, Dr D Dickens
 1 June 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Drug metabolism - prediction, detection, and isolation

University of Birmingham School of Pharmacy
Electrosynthesis (ES) is a green methodology for preparing and interpreting drug metabolites linked to toxicology. ES describes the synthesis of chemical compounds in an electrochemical cell. Read more
 Supervisor: Dr M Jones
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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